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Question
Posted by: HUGO | 2007/03/14

CHROMOGRANIN

Beste Dr

Ek het laas week aan u geskryf ivm die verhoogde chromogranin en u het my verwys na 'n interessante webbladsy. Probleem is net: beide die 5HIAA en Catecholemines het normaal getoets.

Dit terwyl die Chromogranin A verhoog het teenoor verlede jaar se lesing: 27 en nou 36,8.

So die vraag is: wat kan nog die CgA se waarde verhoog?

Baie dankie vir die moeite

Groete

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Our expert says:
Expert ImageCyberDoc

Hallo Hugo
Al wat ek kry is kankers en nierversaking? Het hulle gecheck vir prostaat kanker en longkanker ook - ( PSA bloed toets, en bronchiale spoeling dalk nuttig om ook te doen?)

Chromogranin A has been used as an immunohistochemical marker for normal and neoplastic neuroendocrine tissues.4 Elevated plasma concentrations have been demonstrated in patients with tumors of endocrine origin and levels have been shown to correlate with tumor volume.5 Several studies suggest that measurement of plasma chromogranin A may be a valuable diagnostic in subjects with tumors such as pheochromocytoma, carcinoid tumor, neuroblastoma, and small cell lung carcinoma.6 Neuroendocrine tumors that secrete no other hormone markers, referred to as “nonfunctioning” tumors, can sometimes be detected serologically because they retain the ability to secrete chromogranin A. Chromogranin A is more stable than serotonin, making its measurement a useful alternative for the detection of carcinoid tumor.7 Elevated levels of chromogranin A in patients with prostate cancer have been shown to correlate with poor prognosis.

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