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Updated 14 February 2013

Your complete guide to lycopene

Lycopene is an antioxidant which has been linked to a reduced incidence of cancer, cardiovascular disease, and macular degeneration.


RELATED TERMS

BACKGROUND

There is no well-established definition of "lycopene deficiency," and direct evidence that repletion of low lycopene levels has any benefit is lacking.

EVIDENCE TABLE

Conditions

Uses
disclaimer: These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.
Grade*

Antioxidant

C

Asthma caused by exercise

C

Atherosclerosis (coronary artery disease)

C

Benign prostate hyperplasia (BPH)

C

Breast cancer prevention

C

Cancer prevention (general)

C

Cervical cancer prevention

C

Eye disorders (age-related macular degeneration prevention, cataracts)

C

Gastrointestinal tract and colorectal cancer prevention

C

Gingivitis

C

High blood pressure

C

High blood pressure associated with pregnancy (pre-eclampsia)

C

Infertility

C

Kidney disease

C

Lung cancer prevention

C

Oral mucositis

C

Ovarian cancer (prevention)

C

Prostate cancer

C

Sun protection

C

Immune stimulation

D

Lung function after exercise

D

TRADITION

DOSING

Adults (18 years and older)

Children (younger than 18 years)

SAFETY

Allergies

Side Effects and Warnings

Pregnancy and Breastfeeding

INTERACTIONS

Interactions with Drugs

Interactions with Herbs and Dietary Supplements

ATTRIBUTION

  • Ansari MS, Gupta NP. A comparison of lycopene and orchidectomy vs. orchidectomy alone in the management of advanced prostate cancer. BJU Int 2003;92(4):375-378. View abstract
  • Bowen P, Chen L, Stacewicz-Sapuntzakis M, et al. Tomato sauce supplementation and prostate cancer: lycopene accumulation and modulation of biomarkers of carcinogenesis. Exp Biol Med (Maywood) 2002;227(10):886-893. View abstract
  • Briviba K, Kulling SE, Moseneder J, et al. Effects of supplementing a low-carotenoid diet with a tomato extract for 2 weeks on endogenous levels of DNA single strand breaks and immune functions in healthy non-smokers and smokers. Carcinogenesis 2004;25(12):2373-2378. View abstract
  • Bunker CH, McDonald AC, Evans RW, et al. A randomized trial of lycopene supplementation in Tobago men with high prostate cancer risk. Nutr Cancer 2007;57(2):130-7. View abstract
  • Chandra RV, Prabhuji ML, Roopa DA, et al. Efficacy of lycopene in the treatment of gingivitis: a randomised, placebo-controlled clinical trial. Oral Health Prev Dent 2007;5(4):327-36. View abstract
  • Chong EW, Wong TY, Kreis AJ, et al. Dietary antioxidants and primary prevention of age related macular degeneration: systematic review and meta-analysis. BMJ 2007 Oct 13;335(7623):755. View abstract
  • Clark PE, Hall MC, Borden LS Jr, et al. Phase I-II prospective dose-escalating trial of lycopene in patients with biochemical relapse of prostate cancer after definitive local therapy. Urology 2006 Jun;67(6):1257-61. View abstract
  • Gianetti J, Pedrinelli R, Petrucci R, et al. Inverse association between carotid intima-media thickness and the antioxidant lycopene in atherosclerosis. Am Heart J 2002;143(3):467-474. View abstract
  • Giovannucci E, Rimm EB, Liu Y, et al. A prospective study of tomato products, lycopene, and prostate cancer risk. J Natl Cancer Inst 2002;94(5):391-398. View abstract
  • Gupta NP, Kumar R. Lycopene therapy in idiopathic male infertility—a preliminary report. Int Urol Nephrol 2002;34(3):369-372. View abstract
  • Jatoi A, Burch P, Hillman D, et al. A tomato-based, lycopene-containing intervention for androgen-independent prostate cancer: results of a Phase II study from the North Central Cancer Treatment Group. Urology 2007 Feb;69(2):289-94. View abstract
  • Kumar A, Bagewadi A, Keluskar V, et al. Efficacy of lycopene in the management of oral submucous fibrosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007 Feb;103(2):207-13. View abstract
  • Schwarz S, Oberm©ller-Jevic UC, Hellmis E, et al. Lycopene inhibits disease progression in patients with benign prostate hyperplasia. J Nutr 2008 Jan;138(1):49-53. View abstract
  • Singh M, Krishanappa R, Bagewadi A, et al. Efficacy of oral lycopene in the treatment of oral leukoplakia. Oral Oncol 2004;40(6):591-596. View abstract
  • Vaishampayan U, Hussain M, Banerjee M, et al. Lycopene and soy isoflavones in the treatment of prostate cancer. Nutr Cancer 2007;59(1):1-7. View abstract



 
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