12 January 2012

Fraudulent red wine/heart research

A researcher who studied the link between ageing and red wine has committed more than 100 acts of data fabrication and falsification, throwing much of his work into doubt.

A University of Connecticut researcher who studied the link between ageing and a substance found in red wine has committed more than 100 acts of data fabrication and falsification, the university said, throwing much of his work into doubt.

Dr Dipak K. Das, who directed the university's Cardiovascular Research Centre, studied resveratrol, touted by a number of scientists and companies as a way to slow aging or remain healthy.

Among his findings, according to a University of Connecticut press release in 2007, was that "the pulp of grapes is as heart-healthy as the skin, even though the antioxidant properties differ."

"We have a responsibility to correct the scientific record and inform peer researchers across the country," Philip Austin, the university's interim vice president for health affairs, said in a statement.

The university said an anonymous tip to the US Office of Research Integrity, which investigates alleged misconduct by federal grant recipients, led to an investigation that began in 2008.

Results of the investigation

The result was a 60 000-page report by UConn faculty outlining 145 counts of fabrication and falsification of data. Other members of Dr Das' laboratory may have been involved and are being investigated, the report continues.

UConn has "declined to accept $890 000 (about R 7.2 million) in federal grants" awarded to Dr Das, according to the statement, and has begun dismissal proceedings. The university has alerted 11 journals that published his work.

The journals include Antioxidants & Redox Signaling, where Dr Das was one of the editors in chief, and the Journal of Agriculture and Food Chemistry.

Although many scientists have been sceptical of various claims made about resveratrol, it has garnered significant commercial interest. GlaxoSmithKline bought Sirtris, a company that worked on the compound in 2008 for $720 million (about R5.8 billion), but later discontinued work on one version of a drug that mimics its activity because of disappointing results.

A Las Vegas resveratrol maker called Longevinex has promoted Dr Das' research, and he appears in a lengthy video touting the nutrient as the next aspirin.

Dr Das also shared a 2002 patent on the use of another compound in grape skins called proanthocyanidin to prevent and treat heart conditions.

Other scientists have taken notice of Dr Das' work, citing 30 of his papers more than 100 times each, according to Thomson Scientific's Web of Knowledge. Last year, he won an award from the International Association of Cardiologists.

Minimal impact

Still, one longevity researcher said the impact of the fraud on the field will be minimal.

"There are many investigators who are working on resveratrol," said Dr Nir Barzilai, of Albert Einstein College of Medicine. "That doesn't mean we know the whole truth. But Rome wasn't built on Dr Das."

Dr Das, who could not be reached for comment, said in a 2010 letter to university officials that the investigation was a "conspiracy" against him. The work was "repeated by many scientists all over the world," he wrote.

"As you know, because of the development of tremendous amount of stress in my work environment in recent months, I became a victim of stroke for which I am undergoing treatment," he wrote in a separate letter.

(Reuters Health, Adam Marcus and Ivan Oransky MD, January 2012)


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