Oestrogen helps trauma victims

Gender-specific hormones may explain why premenopausal women are more likely than men to survive severe physical injuries, say researchers.

Their analysis of national data from more than 48,000 patients who suffered severe trauma showed that women are 14% more likely to survive than similarly injured men. This difference may be due to the negative impact of male sex hormones on a stressed immune system.

The effect was limited to patients aged 13 to 64. Sex hormones haven't developed in younger patients and their activity is significantly reduced in older patients, explained the Johns Hopkins University School of Medicine researchers.

The study was published in The Journal of Trauma.

The findings

Both women and men have oestrogens (female sex hormones) and androgens (male sex hormones, including testosterone), but they have them in different ratios that change over time. After a person suffers a serious injury, sex hormones appear to have specialised roles in regulating metabolic, cardiovascular and immune reactions, the researchers said.

These findings may lead to new ways to improve survival among male trauma patients, such as giving them androgen-blocking drugs.

"Female sex hormones appear to give women better resiliency to extreme injury, while male sex hormones seem to worsen their survival after trauma," study leader Dr Adil H. Haider, an assistant professor of surgery, said. "And if we can find a way to manipulate those hormones in men, for example by temporarily blocking sex hormones, we may be able to improve their survival."

(Copyright © 2010 HealthDay. All rights reserved.)