Thinking difficulties have been reported in patients taking topiramate, the authors explain, but they have never been defined and assessed with the aid of standardised tests.

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Problems tied to pill
Eight patients in the topiramate group experienced language problems compared with none of the patients in the other groups.

Language disturbances generally occurred within the first month of treatment, were of mild severity, and did not require further adjustment of dosages or discontinuation of topiramate.

The disturbances included difficulty finding words, slowing of verbal expression, changes of one word with another with the same meaning, need to search for the right word, production of nonexistent words deriving from the fusion of two words, or occasional difficulty in naming objects.

The presence of anxiety or depression worsened performance on some of the tests, the report indicates.

In light of these findings, the researchers call for further studies comparing topiramate with similar drugs.

SOURCE: Headache, January 2008. – (Reuters Health)

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Headache and migraine Centre

February 2008
 

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