These cellular structures, called GW bodies, play an important role in gene regulation (RNA interference), according to a team from the University of Florida, Gainesville.

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The discovery marks a major shift in the understanding of cell biology, and could aid the development of treatments for cancer and autoimmune diseases. It might also improve gene therapy, the researchers say.

Helps regulate microRNA
GW bodies are located in the jelly-like cytoplasm that surrounds the nucleus, and appear to help regulate genetic material called microRNA. MicroRNA typically switch genes off to control cell reproduction and development, but the Florida team found this process functioned poorly when GW bodies were absent.

The study appears in the online issue of Nature Cell Biology.

"The significance of our study is that it is one of the first to stress the importance of this pathway with respect to cell biology by demonstrating that the specific micro-environments of the GW bodies within the cell appear to be crucial for the proper functioning of the RNA interference process," Andrew Jakymiw, a postdoctoral associate in the department of oral biology, said in a prepared statement.

"This RNA interference pathway is revolutionising the way people do research and potentially the way people may apply therapies," Jakymiw said. – (HealthDayNews)

Visit our Genetics Centre for more information.

December 2005
 

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