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Increased levels of the protein, called cyclin D, overstimulate a molecular switch known as CDK4 kinase, which in turn triggers the uncontrolled proliferation of malignant cells, the scientists report in the current Cancer Cell.

If those cancer cells also contain an oncogenic form of the HER2 gene, they can be especially virulent.

Drug shows potent activity
However, the drug Herceptin has shown potent activity in blocking HER2 cells, and other anti-cancer agents such as Gleevec work by blocking kinases.

As reported by the BBC Saturday, the Boston researchers say it should be possible to develop a drug targeted specifically to CDK4. Using that drug in combination with Herceptin could be highly effective therapy for women with very aggressive breast tumours, they said. – (HealthDayNews)

Read more: Breast Cancer Centre

(January 2006)
 

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