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On the other hand all forms of chronic prostatitis are difficult to treat. Standard antibiotics penetrate the prostate poorly. Quinolones and trimethoprim-sulphametoxazole penetrate the prostate fairly well. Resistance to trimethoprim-sulphametoxazole is, however, fairly common.

Chronic prostatitis is likely to recur despite treatment, but symptoms are milder and can be reduced by changes in lifestyle. Treatment lasts between six and eight weeks.

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