The increase in body weight and total body fat is associated with a shift of fat from the peripheral sites of the body to the abdomen. In certain women this causes a change in shape from the more gynaecoid (female-like) to the android (male-like) fat distribution which is thought to carry an increased risk for the development of cardiovascular disease.

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In the breasts, the glandular tissue undergoes atrophy (becomes less) and is replaced by fat.

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