Many factors have been shown to predict the outcome in a patient with a glomerulonephritis as the primary diagnosis. These factors differ slightly for the various renal syndromes, but certain general guidelines hold true.

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The following factors are important in prognosis:

• The renal function at presentation: The worse the degree of renal failure, the worse the final outcome tends to be.
• High blood pressure: Lowering blood pressure in hypertensive patients has been shown to decrease the rate of decline of renal function. Aggressive blood pressure control is a very important aspect in the management of these patients.
• The degree of proteinuria: The higher the degree of protein loss in the urine, the faster renal functions tend to deteriorate.
• The specific histopathological subtype: Some types (e.g. focal segmental glomerulosclerosis) fare worse than others (e.g. minimal change nephropathy).
• The renal syndrome: Uncomplicated nephritic syndrome rarely leads to long-term problems, whereas severe nephrotic syndrome, rapidly progressive renal failure and chronic renal failure often do.

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