Serious side-effects are rare, and should not happen if the administering doctor keeps the safe amounts of local anaesthetics in mind, and takes utmost care not to inject any of it immediately into the bloodstream.
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The side-effects of local anaesthetics can be very dangerous and are mainly seen when too much is administered, or if inadvertently or accidentally injected straight into the bloodstream.
The side-effects on the brain are a numb feeling around the mouth and in the tongue, anxiety or excitement, tremors or twitching, which can proceed to convulsions and total loss of consciousness. This can be associated with total cardio-vascular collapse and respiratory arrest (stopping of breathing).
The other organ that can be dangerously affected is the heart: slowing of the heart rate, low blood pressure, proceeding to total cardiovascular collapse.
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