People who have mutations of a gene known as Epac are more likely to start smoking and become addicted to nicotine, according to researchers at Virginia Commonwealth University.
Noting a tendency among twins to start smoking and become hooked, the scientists studied 688 twins, finding that a common mutation of the Epac gene was shown to have a modest association with nicotine dependence. And a different mutation appeared to have a weaker association with starting to smoke, the researchers point out in a prepared statement.
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The Epac gene, located on chromosome 12, has been shown to become more active in a rat's brain after the animal has been given nicotine, the researchers say.
While past research has found that genes - as well as environmental factors like parents smoking at home - have an influence on whether a person begins smoking and becomes nicotine dependent, no specific gene has been identified that is responsible for an increased tendency to smoke, they add. – (HealthDayNews)
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