Scientists have pinpointed an area on a particular chromosome that could make some people susceptible to alcoholism and others prone to depression, says a new study.
The finding may some day make it easier to predict whether a person is likely to have these disorders and could lead to new drug treatments down the line.
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"We found an area on chromosome 1 that appears to be related to a vulnerability to alcoholism or affective disorders," says lead author Dr John Nurnberger, director of the Institute of Psychiatric Research at Indiana University Medical Centre.
That means, he says, that "within families, some people with a gene variant in this area may develop alcoholism and other people with that variant may develop depression."
Chromosomes are rod-shaped structures within the nucleus of cells containing genetic information that determine a person's inherited characteristics.
Although the gene or genes identified by Nurnberger's team don't actually cause alcoholism or depression, they do increase the risk, he says.
"The outcome has to be determined by a multitude of factors, some of which are genetic and some of which are environmental," Nurnberger says.
The study was published in a recent issue of the American Journal of Psychiatry.
Although Nurnberger says his research is an important advance in better understanding alcoholism and depression, he stresses that much more work has to be done.
"What we need to do is find out the exact nature of the gene or genes in that area, and that's what we're working on now," he says.
The research also could lead to more effective drug treatments or tests to identify people who are vulnerable to alcoholism or depression.
"We think there are things we can do about it, but we don't know yet how to design the treatments because we don't know the exact biochemical pathways involved," Nurnberger says.
"There are other instances like that where you have the same area that appears to be involved in multiple illnesses," Nurnberger says. "The flip side of that is you have the same illness, which may be related to many different chromosomal areas. So it's a complex picture."
Mental-health experts say Nurnberger's research is potentially significant.
"I think this is very exciting because what we've known clinically for some time is that many people who are prone to abuse alcohol also are vulnerable to depression. And now we've got some reinforcing genetic information that corroborates our clinical impressions," says Dr Richard Suchinsky, chairman of the American Psychiatric Association's Council on Addiction Psychiatry.
He agrees Nurnberger's research could lead to better treatments for depression and alcoholism.
''We're a ways away from there, but at least it's a big step down the road,'' Suchinsky says.
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