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The more people are vaccinated, the more successful the vaccination programme will be, since there will be fewer people available for the organism to infect. When fewer people are infected, there will be less transmission of the organism, and hopefully the disease can be eradicated. This obviously only holds true for organisms that affect humans exclusively.

Some organisms that cause infection can be found in various wild or domestic animals as well (sometimes without causing disease in these animals). In such cases it would be much more difficult to eradicate the organism completely, but vaccination would still prevent humans from getting the disease.

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