What is the outcome of ankylosing spondylitis?

Pain tends to be persistent early in the disease and then becomes intermittent, with alternating exacerbations and quiet periods.

Onset of the disease in the teenage years correlates with both a worse outlook and more severe hip involvement.

The disease in women tends to be milder with less frequent progression to total spinal fusion (ankylosis). But it appears that women may suffer more from peripheral arthritis and may get late neck problems if they have the disease.

The most serious complication of the spinal disease is spinal fracture, which can occur with even minor trauma. Progressive lung problems are a rare complication of long-standing ankylosing spondylitis.

Heart valve problems and problems with the electrical conduction system of the heart increase with prolonged disease.

However, most patients with ankylosing spondylitis do not experience disabling symptoms and are able to lead a normal life.