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11 March 2009

HPV vaccine for boys?

Studies are being conducted to determine if the HPV vaccine is effective in boys - if the findings are positive it could drastically cut the transmission of the killer virus.

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More than half of all people will have a sexually transmitted disease or infection at some point in their life, the American Social Health Association reports.

One of the least noticeable, but potentially most life-threatening infections, is the human papillomavirus, or HPV.

Most HPV carriers are never diagnosed and never realise they carry the virus.

"It's never detected, they are never aware of it, and their immune system suppresses it before they ever know about it in the vast majority of cases," said Fred Wyand, spokesman for the American Social Health Association.

In this way, HPV is a silent killer. It's the leading cause of cervical cancer and has become the second-leading cause of cancer death for women around the globe.

Doctors have responded to the threat of HPV by fighting it in a way unusual among sexually transmitted diseases - through a vaccine. The US Centers for Disease Control and Prevention has recommended that 11- and 12-year-old girls begin receiving the vaccine as part of school vaccination efforts.

Vaccine will prevent transmission
Now researchers are looking into whether the vaccine should be given to boys as well, both to prevent the transmission of HPV, and to prevent the rarer, but no less deadly, cancers that can occur in men from the virus.

"There is probably no reason to think it would not be effective in boys, and because HPV is passed back and forth, immunising a large part of the population would limit transmission," said Dr Jonathan L. Temte, associate professor in the Department of Family Medicine at the University of Wisconsin School of Medicine and Public Health.

"However, we're still very early in the life span of this vaccine. It's been less than a year since a recommendation was issued. It is premature to discuss giving it to boys until there's proof of its efficacy," added Temte, who also serves as the American Academy of Family Practitioners' liaison to the Advisory Committee on Immunisation Practices.

Studies have shown HPV to kill an estimated 240 000 women worldwide each year through cervical cancer. And infection with HPV via oral sex also has been proven to be the leading cause of throat cancer, striking 11 000 American men and women each year.

Research continues to find that the vaccine is very effective in preventing HPV-caused cervical cancer. Two studies last year involving almost 18 000 girls and women found that the vaccine was nearly 100 percent effective in preventing precancerous cervical lesions from the four HPV strains targeted by the vaccine.

The studies also found that the vaccine is much more effective when given to girls or young women before they become sexually active.

Could cut risk of throat, genital and anal cancers
Although men don't risk cervical cancer, they are half of the equation when it comes to sexually transmitted diseases. They also face increased risks for throat, genital and anal cancers from HPV infection.

The maker of one of the vaccines, Merck & Co., is accumulating data to consider whether boys should receive the inoculation as well.

"Nobody will be surprised if someday it is recommended for boys, but it's premature to make that call now," Wyand said. "The early returns I'm aware of with boys are positive. The vaccine appears to trigger an immune response similar to that of girls."

Researchers are also looking at a vaccine that could prevent herpes simplex, the cause of genital herpes. "There are going to be a few years out before we see anything like that," Temte said. – (Dennis Thompson/HealthDay News, June 2008)

Read more:
Human Papillomavirus
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