18 January 2011

Mom's diet affects baby's brain

Eating less, or dieting, during early pregnancy can lead to impaired foetal brain development researchers report.


Eating less, or dieting, during early pregnancy can lead to impaired foetal brain development researchers from The University of Texas Health Science Centre reported.

The researchers found decreased formation of cell-to-cell connections, cell division and amounts of growth factors in the foetuses of mothers fed a reduced diet during the first half of pregnancy.

"This is a critical time window when many of the neurons as well as the supporting cells in the brain are born," said Dr Peter Nathanielsz, director of the Centre for Pregnancy and Newborn Research in the Health Science Center School of Medicine.

The team compared two groups of baboon mothers located at SFBR's Southwest National Primate Research Centre. One group ate as much as they wanted during the first half of pregnancy while the other group was fed 30% less, a level of nutrition similar to what many prospective mothers in the US experience.

Hundreds of genes involved

"Our collaboration allowed us to determine that the nutritional environment impacts the foetal brain at both the cellular and molecular levels," said SFBR's Laura Cox, Ph.D. "That is, we found dysregulation of hundreds of genes, many of which are known to be key regulators in cell growth and development, indicating that nutrition plays a major role during foetal development by regulating the basic cellular machinery."

Moderate versus severe reduction

It is known that marked nutrient restriction, such as in famine conditions, adversely affects development of the foetal brain. Senior author Thomas McDonald, Ph.D., also of the Health Science Centre, said the study "is the first demonstration of major effects caused by the levels of food insecurity that occur in sections of US society and demonstrates the vulnerability of the foetus to moderate reduction in nutrients."

Dr Nathanielsz noted:

  • In teenage pregnancy, the developing foetus is deprived of nutrients by the needs of the growing mother;
  • In pregnancies late in reproductive life, a woman's arteries are stiffer and the blood supply to the uterus decreases, inevitably affecting nutrient delivery to the fetus;
  • Diseases such as pre-eclampsia or high blood pressure in pregnancy can lead to decreased function of the placenta with decreased delivery of nutrients to the foetus.

'Lifetime effects'

"This study is a further demonstration of the importance of good maternal health and diet," McDonald said. "It supports the view that poor diets in pregnancy can alter development of foetal organs, in this case the brain, in ways that will have lifetime effects on offspring, potentially lowering IQ and predisposing to behavioural problems."

Developmental programming of lifetime health has been shown to play a role in later development of obesity, diabetes and heart disease. In light of this new finding, research should focus on effects of developmental programming in the context of autism, depression, schizophrenia and other brain disorders.

Mother's protection

The study, published in Proceedings of the National Academy of Sciences, also forces researchers to review the commonly held notion that during pregnancy the mother is able to protect the foetus from dietary challenges such as poor nutrition, McDonald said.

The non-human primate model's brain developmental stages are very close to those of human foetuses, the researchers noted. Most previous research in this area was conducted in rats. - (EurekAlert!, January 2011)

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Nutrition in pregnancy


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