Donating eggs does not appear to hurt a woman's chances of becoming pregnant in the years after the procedure, a small study from Belgium found. Few other studies have looked at the effects of egg-harvesting procedures on the future reproductive health of women who donate eggs.
Some experts question whether hormonally stimulating the ovaries and harvesting eggs from a healthy young woman could later increase her chance of infertility, but others contend there are no serious long-term risks.
"Egg donation has been offered to patients in Belgium since the 1980s. We were not surprised by the good reproductive outcomes in ex-egg donors," Dr Dominic Stoop, medical director at the Center for Reproductive Medicine in Brussels, Belgium and lead author of the study, said.
How the study was done
The researchers administered a telephone questionnaire to 194 women who had donated eggs at the Belgian center between 1999 and 2010. The surveys were conducted an average of four to five years after those procedures. At the time of donation, women averaged 30 years old.
Sixty egg donors reported trying to get pregnant since the procedure. Of those, 57 conceived without help. The other three women required fertility treatment, although two of them sought treatment because of their partner's infertility.
Menstrual cycle after egg donation
Sixteen percent of donors had changes in their menstrual cycle after donation. However, none of the women reporting these changes had fertility problems.
"Menstrual pattern could be disrupted temporarily by hormonal changes due to ovarian stimulation, much like how menstrual changes also appear after stopping an oral contraceptive," said Dr Stoop, whose study was published online in Fertility and Sterility.
"In the short term, egg donation appears to have no effect on fertility," said Dr Orhan Bukulmez, an infertility specialist at University of Texas Southwestern Medical Center in Dallas who wasn't involved in the new research. But longer-term studies of egg donors are needed, he said.
Although some researchers argue that the extra hormones given before the procedure and possible trauma to the ovaries could lead to early menopause in egg donors, studies haven't confirmed those fears. Dr Bukulmez cautioned that the results of the current study cannot be generalised to include women seeking to freeze their own eggs.
Egg donors are a very select group of patients that are chosen for their healthy ovaries, he said, adding, "They may not be representative of the fertile female population as a whole."
(Reuters Health, Lindsey Konkel, April 2012)