22 December 2016

Shorter course of antibiotics bad for kids' ear infections

A shortened five-day course of antibiotics in the case of youngsters with ear infections showed no benefits over a standard 10-day course.


A shorter period of antibiotic treatment for ear infections in young children does more harm than good, a new study finds.

Significant concerns

About three-quarters of children have ear infections in their first year of life. These infections are the most common reason why children are given antibiotics, the University of Pittsburgh researchers noted.

"Given significant concerns regarding overuse of antibiotics and increased antibiotic resistance, we conducted this trial to see if reducing the duration of antibiotic treatment would be equally effective along with decreased antibiotic resistance and fewer adverse reactions," Dr Alejandro Hoberman said in a university news release. Hoberman is chief of the general academic paediatrics division at Children's Hospital of Pittsburgh of UPMC.

The study included 520 youngsters with ear infections. The children ranged in age from nine months to 23 months, and were randomly selected to receive either a standard 10-day course of antibiotics or a shortened five-day course of antibiotics followed by five days of placebos.

Read: Get smart about antibiotics

The risk of treatment failure was 34 percent in the five-day group and 16 percent in the 10-day group. What's more, the children in the five-day group didn't have a lower risk of antibiotic resistance or of side effects such as diarrhoea or diaper rash.

"The results of this study clearly show that for treating ear infections in children between nine and 23 months of age, a five-day course of antibiotic offers no benefit in terms of adverse events or antibiotic resistance," Hoberman said.

"Though we should be rightly concerned about the emergence of resistance overall for this condition, the benefits of the 10-day regimen greatly outweigh the risks," he added.

The study was published in the New England Journal of Medicine.

Read more:

Use antibiotics wisely

Antibiotics overused in hospitals

When were antibiotics first used?

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