Children who develop autism already show signs of different brain responses in their first year of life, scientists said on Thursday in a study that may in the future help doctors diagnose the disorder earlier.
British researchers studied 104 babies at six to 10 months and then again at three-years-old, and found that those who went on to develop autism had unusual patterns of brain activity in response to eye contact with another person.
The findings, published online in Current Biology, suggest direct brain measures might help predict the future risk of autism in babies as young as six months old, said Dr Mark Johnson director of the Centre for Brain and Cognitive Development at Birkbeck College, University of London, who led the study.
Characteristic autistic behaviour tends not to emerge before the age of two years and firm diagnoses are usually only made after this age.
"Because there are no good behavioural signs at this young age (under one year), we wanted to see whether, by measuring the activity of the brain in a more direct way, we might be able to pick up earlier warning signs," Dr Johnson said in a telephone interview.
Siblings with autism
His team looked at babies at greater risk of developing autism later in life because they had an older brother or sister with the condition.
The researchers used passive sensors placed on the scalp to register brain activity while the babies viewed faces that switched from looking at them to looking away.
The babies who were later found to be typically developing children showed a clear difference in brain activity in response to a face looking towards them compared to a face looking away.
In contrast, most of the babies who later went on to develop autism symptoms showed much less of a difference in brain activity when someone made eye contact and then looked away.
The researchers cautioned, however, that the predictive markers were not 100% accurate, as the study did find cases of babies who showed no differences in brain function and were not later diagnosed, and vice versa.
Dr Johnson said the results were a first step towards earlier autism diagnosis, but added that more research was needed to confirm and strengthen the brain activity markers.
- (Kate Kelland, Reuters Health, January 2012)
Autism leads to other developmental disorders