Addiction is the continued or compulsive use of a substance,
despite negative and/or harmful consequences. Over the years, addiction has
come to be re-defined to include behaviours, as well as substances, and the
term is now used to describe significant problems with alcohol, nicotine,
drugs, gambling, internet use, and sex.
The 'major' addictions, like alcoholism and drug abuse,
stimulate significant amounts of research and are now largely well characterised,
but others, like pathological gambling and internet addiction, are much less
And then there is food. Food is a biological necessity, a
distinction that makes it unlike any of the other substances or behaviours
typically considered as addictive. It therefore also doesn't qualify when
considering the typical conditions of abnormal dependence upon a substance –
tolerance and withdrawal.
Binge eating a new
At the same time, research has long found similarities
between food intake and addiction. And just recently announced, the updated
version of the Diagnostic and Statistical Manual of Mental Disorders, commonly
called the DSM, will now formally include binge eating disorder as a new
Neuroimaging work has revealed that the same regions of the
brain process the reinforcing effects of food and the consumption of drugs of
abuse. The overlap of these neural circuits, however, does not necessarily mean
that food is, or can be, addictive.
This lack of clarity in the scientific literature prompted
the publication of this cohesive look at the support for and against the
application of the addiction model to food. This Biological Psychiatry issue
was led by guest editors Drs. Dana Small and Ralph DiLeone, at the Yale School
of Medicine. Their goal was to bring together original research findings,
systematic reviews and opinions of key leaders in the field to objectively
represent the state of the field and both sides of the debate.
"While it is attractive to use the addiction framework
to 'jump start' and guide our understanding of how neural circuits of reward
and self-control might contribute to understanding overeating and the obesity
epidemic, the price of adopting an inappropriate framework would be high,"
note Small and DiLeone. "For example, an inappropriate adaptation might
steer research towards evaluating variables that have been shown to be critical
for addiction at the expense of those that are unique to obesity and perhaps
key to understanding overeating."
Papers in this issue cover the common and divergent
neurobiological mechanisms and characteristics of food and substances of abuse.
One provides rationale for adopting the food addiction model, arguing that food
addiction exists and that although food is less powerful than addictive drugs,
this does not diminish the compulsive nature or lack of control associated with
binge eating. In contrast, another paper argues that the concept of food
addiction is problematic and its links to drug addiction are overstated.
The brain and
These juxtaposed papers are followed by reviews outlining
the differences and similarities in brain reward circuitry, covering obesity,
addiction, impulsivity, and self-control. The role that dopamine, a
neurotransmitter critically involved in pleasure and reward, plays in food is
Others cover the theme of neural adaptations, where new
papers detail research findings on the changes observed in the brain following
reward-driven feeding, reward and habit responding, and the effects of a
high-fat diet. Another series of papers examine risk factors and
susceptibility, including stress levels and how weight is related to an
individual's degree of reward responding.
Binge eating disorder, the newest diagnosis within the
eating disorder category of mental illnesses, is not left out. In fact, Small
and DiLeone explain that the papers presented here provide a strong consensus,
suggesting that binge eating may represent a sub-type of obesity most closely
related to drug addiction.
Experts also comment on future directions for additional
research and policy implications, considering how the verdict to adopt or
reject the addiction framework will influence the national debate of how to
address issues of diet, nutrition and obesity prevention.