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Updated 18 February 2013

Corn poppy (Papaver rhoeas)

Corn poppy (Papaver rhoeas) is well known for its showy red flowers and should not be confused with the opium poppy (Papaver somniferum). In the Mediterranean, corn poppy greens are eaten as a vegetable.

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RELATED TERMS

Alkaloids, anthocyanins, astragaline, coptisine, depsides, field poppy, Flanders poppy, flavonoids, glaudine, glycosides, hyperoside, hypolaetin, isocorydine, isoquercitrine, kaempferol, luteolin, Papaveraceae (family), Papaver rhoeas, p-hydroxybenzoic acid, protocatechuic acid, quercetin, red corn poppy, red poppy, rhoeadine, stylopine, wild poppy.

BACKGROUND

Corn poppy (Papaver rhoeas) is well known for its showy red flowers and should not be confused with the opium poppy (Papaver somniferum). In the Mediterranean, corn poppy greens are eaten as a vegetable.

Corn poppy extracts may reduce morphine withdrawal symptoms. However, there is insufficient available evidence in humans to support the use of corn poppy for any indication. Corn poppy may have iron-chelating activities and should be used cautiously in patients undergoing chelation therapy, or with thalassemia or anemia.

EVIDENCE TABLE

Conditions

Uses
disclaimer: These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.
Grade*

*Key to grades: A: Strong scientific evidence for this use; B: Good scientific evidence for this use; C: Unclear scientific evidence for this use; D: Fair scientific evidence against this use (it may not work); F: Strong scientific evidence against this use (it likely does not work).

TRADITION

The below uses are based on tradition, scientific theories, or limited research. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. There may be other proposed uses that are not listed below. Antioxidant, chelating agent (heavy metals), food uses, gastric ulcers, morphine withdrawal, sedative.

DOSING

disclaimer: The below doses are based on scientific research, publications, traditional use, or expert opinion. Many herbs and supplements have not been thoroughly tested, and safety and effectiveness may not be proven. Brands may be made differently, with variable ingredients, even within the same brand. The below doses may not apply to all products. You should read product labels, and discuss doses with a qualified healthcare provider before starting therapy.

Adults (over 18 years old)

There is no proven safe or effective dose for corn poppy in adults.

Children (under 18 years old)

There is no proven safe or effective dose for corn poppy in children.

SAFETY

disclaimer: The U.S. Food and Drug Administration does not strictly regulate herbs and supplements. There is no guarantee of strength, purity or safety of products, and effects may vary. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy. Consult a healthcare provider immediately if you experience side effects.

Allergies

Avoid with a known allergy or hypersensitivity to corn poppy. Corn poppy flowers may cause hives in allergic individuals.

Side Effects and Warnings

Corn poppy is likely safe when the leaves, petals, and seeds are used in food amounts.

There is little information currently available about the adverse effects associated with corn poppy. However, there have been reports of contact urticaria (hives) due to the flowers.

Use cautiously in patients undergoing chelation therapy, with thalassemia (blood disorders), or with anemia (red blood cell deficiency), as corn poppy may have iron-chelating activities.

Use cautiously in patients taking sedatives, as corn poppy may cause drowsiness.

Pregnancy and Breastfeeding

Corn poppy is not recommended in pregnant or breastfeeding women due to a lack of available scientific evidence.

INTERACTIONS

disclaimer: Most herbs and supplements have not been thoroughly tested for interactions with other herbs, supplements, drugs, or foods. The interactions listed below are based on reports in scientific publications, laboratory experiments, or traditional use. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy.

Interactions with Drugs

Corn poppy may have antioxidant properties.

Corn poppy root may have potent antiulcerogenic effects. Use cautiously with anti-ulcer medications due to possible additive effects.

Corn poppy greens may possess iron-chelating activities. Use cautiously with heavy metal antagonists, chelating agents, and iron salts.

Corn poppy extracts may decrease morphine withdrawal symptoms.

Corn poppy may increase the amount of drowsiness caused by some drugs. Examples include benzodiazepines such as lorazepam (Ativan©) or diazepam (Valium©), barbituates such as Phenobarbital, narcotics such as codeine, some antidepressants, and alcohol. Caution is advised while driving or operating machinery.

Interactions with Herbs and Dietary Supplements

Corn poppy may have antioxidant properties.

Corn poppy root may have potent antiulcerogenic effects. Use cautiously with anti-ulcer herbs and supplements due to possible additive effects.

Corn poppy greens may possess iron-chelating activities. Use cautiously with heavy metal antagonists, chelating agents, and iron supplements.

Corn poppy extracts may decrease morphine withdrawal symptoms.

Corn poppy may increase the amount of drowsiness caused by some herbs or supplements. Caution is advised while driving or operating machinery.

ATTRIBUTION

This information is based on a systematic review of scientific literature edited and peer-reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com).

  • Awe W, Winkler W. [Alkaloids of corn poppy.]. Arch Pharm Ber.Dtsch.Pharm Ges 1957;290/62(8-9):367-376. View abstract
  • El Masry S, El Ghazooly MG, Omar AA, et al. Alkaloids from Egyptian Papaver rhoeas. Planta Med 1981;41(1):61-64. View abstract
  • El SN, Karakaya S. Radical scavenging and iron-chelating activities of some greens used as traditional dishes in Mediterranean diet. Int J Food Sci Nutr 2004;55(1):67-74. View abstract
  • Franchi GG, Franchi G, Corti P, et al. Microspectrophotometric evaluation of digestibility of pollen grains. Plant Foods Hum.Nutr 1997;50(2):115-126. View abstract
  • Gamboa PM, Jauregui I, Urrutia I, et al. Allergic contact urticaria from poppy flowers (Papaver rhoeas). Contact Dermatitis 1997;37(3):140-141. View abstract
  • Gurbuz I, Ustun O, Yesilada E, et al. Anti-ulcerogenic activity of some plants used as folk remedy in Turkey. J Ethnopharmacol 2003;88(1):93-97. View abstract
  • Hillenbrand M, Zapp J, Becker H. Depsides from the petals of Papaver rhoeas. Planta Med. 2004;70(4):380-382. View abstract
  • Pfeifer S. [On the occurrence of glaudine in opium and Papaver rhoeas L.]. Pharmazie 1965;20(4):240. View abstract
  • Pourmotabbed A, Rostamian B, Manouchehri G, et al. Effects of Papaver rhoeas extract on the expression and development of morphine-dependence in mice. J Ethnopharmacol 2004;95(2-3):431-435. View abstract
  • Sahraei H, Faghih-Monzavi Z, Fatemi SM, et al. Effects of Papaver rhoeas extract on the acquisition and expression of morphine-induced behavioral sensitization in mice. Phytother Res 2006;20(9):737-741. View abstract
  • Sahraei H, Fatemi SM, Pashaei-Rad S, et al. Effects of Papaver rhoeas extract on the acquisition and expression of morphine-induced conditioned place preference in mice. J Ethnopharmacol 2-20-2006;103(3):420-424. View abstract
  • Schaffer S, Schmitt-Schillig S, Muller WE, et al. Antioxidant properties of Mediterranean food plant extracts: geographical differences. J Physiol Pharmacol 2005;56 Suppl 1:115-124. View abstract
  • Soulimani R, Younos C, Jarmouni-Idrissi S, et al. Behavioral and pharmaco-toxicological study of Papaver rhoeas L. in mice. J Ethnopharmacol 3-3-2001;74(3):265-274. View abstract
  • Winkler W, Awe W. [On the structure of rhoeadine isomers isolated from Papaver rhoeas.]. Arch Pharm 1961;294/66:301-306. View abstract
disclaimer: Natural Standard Bottom Line Monograph, Copyright © 2011 (www.naturalstandard.com). Commercial distribution prohibited. This monograph is intended for informational purposes only, and should not be interpreted as specific medical advice. You should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions. disclaimer: While some complementary and alternative techniques have been studied scientifically, high-quality data regarding safety, effectiveness, and mechanism of action are limited or controversial for most therapies. Whenever possible, it is recommended that practitioners be licensed by a recognized professional organization that adheres to clearly published standards. In addition, before starting a new technique or engaging a practitioner, it is recommended that patients speak with their primary healthcare provider(s). Potential benefits, risks (including financial costs), and alternatives should be carefully considered. The below monograph is designed to provide historical background and an overview of clinically-oriented research, and neither advocates for or against the use of a particular therapy. disclaimer: The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

Copyright © 2011 Natural Standard (www.naturalstandard.com)



Copyright © 2011 Natural Standard (www.naturalstandard.com)
 
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