Astragalosides I-IV, Astragalus gummifera, Astragalus lentiginosus, Astragalus membranaceus, Astragalus mollissimus, Astragalus mongholicus, Astragalus propinquus, Astragalus trigonus, astragel, baak kei, beg kei, bei qi, buck qi, calycosin, Fabacea (family), formononetin, gaba-aminobytyric acid, goat's horn, goat's thorn, green dragon, gum dragon, gum tragacanthae, gummi tragacanthae, hoang ky, hog gum, huang-chi, Huang Qi, huangoi, huangqi, hwanggi, isoflavonoids, ji cao, Leguminosae (family), locoweed, membranous milk vetch, milk vetch, milkvetch, Mongolian milk, Mongolian milk vetch, neimeng hhuangqi, ogi, ononin, ougi, Phaca membranacea Fisch., radix astragali, spino santo, Syrian tragacanth, tai shen, tragacanth, trigonosides I-III, wong kei, yellow leader, yellow vetch, Zhongfengnaomitong.
Astragalus products are derived from the roots of Astragalus membranaceus or related species, which are native to China. In traditional Chinese medicine, astragalus is commonly found in mixtures with other herbs, and is used in the treatment of numerous ailments, including heart, liver, and kidney diseases, as well as cancer, viral infections, and immune system disorders. Western herbalists began using astragalus in the 1800s as an ingredient in various tonics. The use of astragalus became popular in the 1980s based on theories about anti-cancer properties, although these proposed effects have not been clearly demonstrated in reliable human studies.
Some medicinal uses of astragalus are based on its proposed immune stimulatory properties, reported in preliminary laboratory and animal experiments, but not conclusively demonstrated in humans. Most astragalus research has been conducted in China, and has not been well designed or reported.
Gummy sap (tragacanth) from astragalus is used as a thickener in ice cream, an emulsifier, a denture adhesive, and an anti-diarrheal agent.
These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.
Astragalus-containing herbal combination formulas may have beneficial effects in aplastic anemia.
According to early research, an astragalus-containing combination formula may reduce fatigue and increase athletic performance. Further research is needed before a conclusion can be made.
Few human studies have investigated astragalus in burn patients. Further research is required before a conclusion can be made.
Chemotherapy side effects
In Chinese medicine, astragalus-containing herbal mixtures are sometimes used with the intention to reduce side effects of cancer treatments. Due to a lack of well-designed research, a firm conclusion cannot be drawn.
Coronary artery disease
In Chinese medicine, herbal mixtures containing astragalus have been used to treat heart diseases. High quality human research is necessary before a conclusion can be drawn.
There is some evidence that astragalus can improve the effectiveness of conventional diabetes therapies. More research is required in this field before recommendations can be made.
There is some evidence that astragalus may offer symptomatic improvement for chronic heart failure. Conclusions cannot be made until well-designed clinical trials have been conducted.
Research suggests that astragalus may have anti-hepatitis effects. Additional study is needed in this area.
Some studies suggest that astragalus may inhibit herpes viruses. Additional research is needed in this area.
Antiviral effects have been reported in early studies. Additional studies are warranted.
Several small studies report that astragalus may stimulate and improve immune system function in conditions such as the common cold, blood disorders, cancer, and HIV/AIDS. Further research is needed in this area.
Research suggests that astragalus may be effective in renal disease. However, there is insufficient evidence to support this claim.
Research suggests that astragalus may be effective in cirrhosis. Further research is required before a conclusion can be made.
There is unclear evidence as to whether astragalus is helpful for reducing menopausal symptoms. Limited study has reported on the use of a combination product and thus the effects of astragalus alone are unknown.
One clinical trial suggests that astragalus may aid in mental performance of children with low IQ. Further, well-designed clinical trials are required before recommendations can be made.
Myocarditis/endocarditis (heart infections)
Several studies suggest that astragalus may improve symptoms of viral myocarditis. However, these studies are small and poorly designed. Larger, higher quality studies are needed in this area.
Astragalus has been used traditionally to aid in smoking cessation. Well-designed clinical trials are required before recommendations can be made.
One clinical trial suggests the potential for benefit of astragalus in patients with tuberculosis. Further well-designed clinical trials are required before recommendations can be made.
Upper respiratory tract infection
Astragalus is often used in Chinese medicine as a part of herbal mixtures to prevent or treat upper respiratory tract infections. Due to a lack of well-designed research, no firm conclusions can be drawn.
*Key to grades:
A: Strong scientific evidence for this use;
B: Good scientific evidence for this use;
C: Unclear scientific evidence for this use;
D: Fair scientific evidence against this use (it may not work);
F: Strong scientific evidence against this use (it likely does not work).
The below uses are based on tradition, scientific theories, or limited research. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. There may be other proposed uses that are not listed below. Acute cerebral infarction, adaptogen, adrenal insufficiency (Addison's disease), aging, AIDS/HIV, allergies, Alzheimer's disease, anemia, angina, ankylosing spondylitis, anorexia, antifungal, anti-inflammatory, antimicrobial, antioxidant, asthma, astringent, blood thinner, blood vessel disorders (vascular endothelial cell proliferation), bone loss, bone marrow production, brain damage (minimal brain dysfunction), bronchitis, cardiac ischemia, cardiomyopathy (hypertrophic), cervicitis, "chi deficiency" (fatigue, weakness, loss of appetite), child birth (preterm labor), chronic fatigue syndrome, cleanser, colitis (in children; rotovirus enterocolitis), cytomegalovirus, dementia, demulcent, denture adhesive (astragalus sap), dermatitis, diabetic foot ulcers, diabetic neuropathy, diarrhea, digestion enhancement, diuretic (urination stimulant), ear infection, edema, expectorant, fatigue, fever, gangrene, gastrointestinal disorders, genetic damage, graft-versus-host disease, hearing damage, hemorrhage (bleeding), hemorrhoids, high blood pressure, high cholesterol, hyperthyroidism, infections, insomnia, joint pain, kidney disorders, laxative, leprosy, leukemia, loss of appetite, low blood platelets, lung cancer, male fertility (sperm motility), memory, menstrual disorders, metabolic disorders, multiple sclerosis, myalgia (muscle pain), myasthenia gravis, nephritis, neuroprotective, night sweats, pain, palpitations, pelvic congestion syndrome, postpartum fever, postpartum urinary retention, prostatitis, psoriasis, pulmonary fibrosis, radioprotection, rectal prolapse, respiratory infections (infantile), shortness of breath, stomach disorders, stomach ulcer, stress, stroke, sweating (excessive), systemic lupus erythematosus (SLE), tissue oxygenation, tonic, tonsillitis, uterine bleeding, uterine prolapse, weight loss, wound healing.
The below doses are based on scientific research, publications, traditional use, or expert opinion. Many herbs and supplements have not been thoroughly tested, and safety and effectiveness may not be proven. Brands may be made differently, with variable ingredients, even within the same brand. The below doses may not apply to all products. You should read product labels, and discuss doses with a qualified healthcare provider before starting therapy.
Adults (over 18 years old)
In Chinese medicine, astragalus is used in soups, teas, extracts, and pills. In practice and in most scientific studies, astragalus is one component of multi-herb mixtures. Therefore, precise dosing of astragalus alone is not clear. Safety and effectiveness are not clearly established for any particular dose. Various doses of astragalus have been used or studied, including 250 to 500 milligrams of extract taken four times daily; 1 to 30 grams of dried root taken daily (doses as high as 60 grams have been reported); or 500 to 1,000 milligrams of root capsules taken three times daily. Dosing of tinctures or fluid extracts depends on the strength of the preparations. A tincture dose (1:5) of 3-6 milliliters three times daily by mouth, or 15 to 30 drops twice daily by mouth has been used. Note that tinctures may have high alcohol content.
For herpes simplex keratitis, 0.5 milliliters astragalus (1:1 extract) for three weeks has been used on the skin. For wound healing, a 10% astragalus ointment has been applied to wound surfaces. The maximum level used is 1.3% when used topically in lotions, denture creams, toothpastes and cosmetics, according to secondary sources
Injections have been used and should only be given under the supervision of a qualified healthcare professional.
Note: In theory, consumption of the tragacanth (gummy sap derived from astragalus) may reduce the absorption of drugs taken by mouth, and they should be taken at separate times.
Children (younger than 18 years)
There is not enough scientific data to recommend astragalus for children.
The U.S. Food and Drug Administration does not strictly regulate herbs and supplements. There is no guarantee of strength, purity or safety of products, and effects may vary. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy. Consult a healthcare provider immediately if you experience side effects.
In theory, patients with allergies to members of the Leguminosae (pea) family may react to astragalus. Cross-reactivity with quillaja bark (soapbark) has been reported for astragalus gum tragacanth.
Side Effects and Warnings
Some species of astragalus have caused poisoning in livestock, although these types are usually not used in human preparations (which primarily include Astragalus membranaceus). Livestock toxicity, referred to as "locoweed" poisoning, has occurred with species that contain swainsonine (Astragalus lentiginosus, Astragalus mollissimus, Astragalus nothrosys, Astragalus pubentissimus, Astragalus thuseri, Astragalus wootoni), or in species that accumulate selenium (Astragalus bisulcatus, Astragalus flavus, Astragalus praelongus, Astragalus saurinus, Astragalus tenellus). Ingestion of certain toxic astragalus plants may cause neurological syndromes, some of which are irreversible.
Overall, it is difficult to determine the side effects or toxicity of astragalus because astragalus is most commonly used in combination with other herbs. There are numerous reports of side effects ranging from mild to deadly in the U.S. Food and Drug Administration (FDA) computer database, although most of these are with multi-ingredient products and they cannot be attributed to astragalus specifically. Side effects reported in people using combination products that contain astragalus include heart palpitations, abdominal discomfort, diarrhea, and aspiration pneumonia.
Astragalus used alone and in recommended doses is traditionally considered to be safe, although safety is not well studied. The most common side effects appear to be mild stomach upset and allergic reactions. In the United States, tragacanth (astragalus gummy sap) has been classified as GRAS (generally recognized as safe) for food use, but astragalus does not have GRAS status.
Based on preliminary animal studies and limited human research, astragalus may decrease blood sugar levels. Caution is advised in patients with diabetes or hypoglycemia, and in those taking drugs, herbs, or supplements that affect blood sugar. Serum glucose levels may need to be monitored by a healthcare professional, and medication adjustments may be necessary.
Based on anecdotal reports and preliminary laboratory research, astragalus may increase the risk of bleeding. Caution is advised in patients with bleeding disorders or taking drugs that may increase the risk of bleeding. Dosing adjustments may be necessary.
Preliminary reports of human use in China have noted decreased blood pressure at lower doses and increased blood pressure at higher doses. Animal research suggests possible blood pressure-lowering effects. Due to a lack of well-designed studies, no firm conclusions can be drawn. Nonetheless, people with abnormal blood pressure or taking blood pressure medications should use caution and be monitored by a qualified healthcare professional. Palpitations have been noted in human reports in China.
Based on animal study, astragalus may act as a diuretic and increase urination. In theory, this may lead to dehydration or metabolic abnormalities. There is one report of pneumonia in an infant after breathing in an herbal medicine powder including Astragalus sarcocolla.
Because astragalus may stimulate the immune system, individuals with autoimmune diseases or organ transplants should consult a healthcare professional before starting therapy. Astragalus is not recommended for people with acute inflammation or acute illness with fever.
Astragalus may increase growth hormone levels.
Pregnancy and Breastfeeding
Astragalus cannot be recommended during pregnancy or breastfeeding due to harmful effects seen in animals.
Many tinctures contain high levels of alcohol and should be avoided during pregnancy.
Most herbs and supplements have not been thoroughly tested for interactions with other herbs, supplements, drugs, or foods. The interactions listed below are based on reports in scientific publications, laboratory experiments, or traditional use. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy.
Interactions with Drugs
Based on preliminary animal studies and limited human research, astragalus may decrease blood sugar levels. Caution is advised in patients with diabetes or hypoglycemia and in those taking drugs that affect blood sugar. Serum glucose levels may need to be monitored by a healthcare provider, and medication adjustments may be necessary.
Preliminary reports of human use in China have noted decreased blood pressure at lower doses and increased blood pressure at higher doses. Animal research suggests possible blood pressure-lowering effects. Although well-designed studies are not available, people taking drugs that affect blood pressure should use caution and be monitored by a qualified healthcare professional. It has been suggested that beta-blocker drugs such as propranolol (Inderal©) or atenolol (Tenormin©) may reduce the effects on the heart of astragalus, although this has not been well studied.
Based on anecdotal reports, astragalus may increase the risk of bleeding when taken with drugs that increase the risk of bleeding. Some examples include aspirin, anticoagulants ("blood thinners") such as warfarin (Coumadin©) or heparin, anti-platelet drugs such as clopidogrel (Plavix©), and non-steroidal anti-inflammatory drugs such as ibuprofen (Motrin©, Advil©) or naproxen (Naprosyn©, Aleve©).
Based on animal research and traditional use, astragalus may act as a diuretic and increase urination. In theory, this may lead to dehydration or metabolic abnormalities (low blood sodium or potassium), particularly when used in combination with diuretic drugs such as furosemide (Lasix©), chlorothiazide (Diuril©), or spironolactone (Aldactone©).
Based on laboratory and animal studies, astragalus may possess immune stimulating properties, although research in humans is not conclusive. Some research suggests that astragalus may interfere with the effects of drugs that suppress the immune system, such as steroids or agents used in organ transplants. Better research is necessary before a firm conclusion can be reached.
Some sources suggest other potential drug interactions, although there is no reliable scientific evidence in these areas. These include reduced effects of astragalus when used with sedative agents such as phenobarbital or hypnotic agents like chloral hydrate; increased effects of astragalus when taken with colchicine; increased effects of paralytics such as pancuronium or succinylcholine when used with astragalus; increased effects of stimulants such as ephedrine or epinephrine; increased side effects of dopamine antagonists such as haloperidol (Haldol©); and increased side effects of the cancer drug procarbazine.
In theory, consumption of the tragacanth (gummy sap derived from astragalus) may reduce absorption of drugs taken by mouth, and should be taken at separate times.
Based on laboratory study, astragalus may be additive to ribavirin, acyclovir, or other antiviral agents.
Activity of lipid lowering (cholesterol lowering) medication may be potentiated.
Based on human study, activity of recombinant interferon 1 may be potentiated by astragalus.
Astragalus may also interact with antibiotics, antivirals and agents that protect against radioactivity.
Interactions with Herbs and Dietary Supplements
Based on preliminary animal studies and limited human research, astragalus may decrease blood sugar levels. Caution is advised in patients with diabetes or hypoglycemia, and in those taking herbs or supplements that affect blood sugar. People using other herbs or supplements that may alter blood sugar levels, should be monitored closely by a healthcare professional while using astragalus. Dosing adjustments may be necessary.
Preliminary reports of human use in China have noted decreased blood pressure at lower doses and increased blood pressure at higher doses. Animal research suggests possible blood pressure-lowering effects. Although well-designed studies are not available, people taking herbs or supplements that affect blood pressure should use caution and be monitored by a qualified healthcare professional.
Based on anecdotal reports, astragalus may increase the risk of bleeding when taken with herbs or supplements that increase the risk of bleeding. Examples include Ginkgo biloba and garlic (Allium sativum).
Based on animal research and traditional use, astragalus may act as a diuretic and increase urination. In theory, this may lead to dehydration or metabolic abnormalities (low blood sodium or potassium), particularly when used in combination with herbs or supplements that may possess diuretic properties.
Based on laboratory and animal studies, astragalus may possess immune stimulating properties, although research in humans is not conclusive. It is not known if astragalus interacts with other agents that are proposed to affect the immune system.
In theory, consumption of tragacanth (gummy sap derived from astragalus) may reduce the absorption of herbs or supplements taken by mouth, and should be taken at separate times.
Based on laboratory study, astragalus may inhibit the actions of immunosuppressants and potentiate the effects of immunostimulant herbs such as echinacea or Panax ginseng.
Activity of lipid lowering (cholesterol lowering) herbs may be potentiated.
Based on laboratory study, astragalus may potentiate the effects of herbs and supplements that protect against radioactivity.
Astragalus may interact with antibacterials, antivirals, CNS stimulants, hypnotics, hormonal herbs and supplements, licorice, rauwolfia alkaloids, and sedatives.
This information is based on a systematic review of scientific literature edited and peer-reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com).
Natural Standard Bottom Line Monograph, Copyright © 2011 (www.naturalstandard.com). Commercial distribution prohibited. This monograph is intended for informational purposes only, and should not be interpreted as specific medical advice. You should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.
While some complementary and alternative techniques have been studied scientifically, high-quality data regarding safety, effectiveness, and mechanism of action are limited or controversial for most therapies. Whenever possible, it is recommended that practitioners be licensed by a recognized professional organization that adheres to clearly published standards. In addition, before starting a new technique or engaging a practitioner, it is recommended that patients speak with their primary healthcare provider(s). Potential benefits, risks (including financial costs), and alternatives should be carefully considered. The below monograph is designed to provide historical background and an overview of clinically-oriented research, and neither advocates for or against the use of a particular therapy.
The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.
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Copyright © 2011 Natural Standard (www.naturalstandard.com)
Copyright © 2011 Natural Standard (www.naturalstandard.com)