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22 December 2016

Compelling clues to causes of dyslexia

A new study suggests that people with dyslexia have 'deficits' that are more general, across the whole brain.

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People with the reading disability dyslexia may have brain differences that are surprisingly wide-ranging, a new study suggests.

Root causes of dyslexia

Using specialised brain imaging, scientists found that adults and children with dyslexia showed less ability to "adapt" to sensory information compared to people without the disorder.

And the differences were seen not only in the brain's response to written words, which would be expected. People with dyslexia also showed less adaptability in response to pictures of faces and objects.

That suggests they have "deficits" that are more general, across the whole brain, said study lead author Tyler Perrachione. He's an assistant professor of speech, hearing and language sciences at Boston University.

The findings, published in the journal Neuron, offer clues to the root causes of dyslexia.

Read: Brain connections may explain dyslexia

Other studies have found that people with dyslexia show differences in the brain's structure and function.

"But it hasn't been clear whether those differences are a cause or consequence of dyslexia," Perrachione explained.

The chicken-and-egg question is tricky, because years of reading, or years of reading disability, affect brain development.

Perrachione said his team thinks it has discovered a cause of dyslexia – partly because the reduced adaptation was seen in young kids, and not only adults.

An important step

A researcher who was not involved in the study called it "groundbreaking".

"Frankly, researchers have struggled with understanding the brain bases of dyslexia," said Guinevere Eden, director of the Centre for the Study of Learning at Georgetown University Medical Centre in Washington, D.C.

Scientists have known that brain structure and function look different in people with dyslexia, Eden said, but they haven't known why.

"This study makes an important step in that direction," she said. "It gets to the true characteristics of the properties of the neurons [cells] in these brain regions, not just their outward appearance."

People with dyslexia have consistent problems with language skills, especially reading.

Read: No link between Dyslexia and IQ

According to the International Dyslexia Association, as much as 15 percent to 20 percent of the population has symptoms of dyslexia – including "slow" reading, poor spelling and writing skills, and problems deciphering words that are similar to each other.

The new study aimed to see whether "neural adaptation" might play a role.

Adaptation is how the brain improves its efficiency. Perrachione offered an example: When you speak to someone for the first time, the brain needs a little time to get used to that person's voice, speaking rhythms and pronunciation of words, for instance.

Functional MRI scans

But then the brain adapts and stops working so hard to process the other person's speech.

In people with dyslexia, however, that adaptation seems to be hindered. "Their brains are working harder to process these sensory inputs," Perrachione said.

The new findings are based on functional MRI scans of adults and children with and without dyslexia. The scans were used to capture the study participants' brain activity as they performed a series of tasks.

In one experiment, the participants listened to a series of words, read either by a single speaker or several different ones. Overall, the researchers found, people without dyslexia adapted to the single voice, but not to multiple speakers.

In contrast, people with dyslexia showed much less adaptation in their brain activity, even when listening to a single speaker. The same pattern was seen when study participants viewed written words.

Read: Brain scans shed light on dyslexia

But the differences went beyond words: People with dyslexia showed less brain adaptation in response to images of faces and objects.

That's "surprising," Eden said, since the disorder does not involve apparent problems with recognising faces or objects.

An astonishing feat

Perrachione speculated on a reason for the findings: The reduced brain adaptation may only "show up" when it comes to reading, because reading is such a complex skill.

The brain has no dedicated "reading" area. "Reading is a tool, or technology, that we've invented," Perrachione pointed out.

Learning to use that technology requires a complex orchestration of different brain "domains", he explained.

And yet, because everyone is expected to read, most people probably do not realise what an accomplishment it is, Perrachione said.

Eden agreed. "Learning to read is an astonishing feat and one that we often take for granted," she said.

Read: Dyslexia may be caused by signal processing problem

Will the new understanding of dyslexia lead to new therapies? It's not clear, both Eden and Perrachione said.

Right now, dyslexia is managed with specialised reading instruction, starting as early as possible. That's not going to change, Eden said.

But if scientists better understand what's happening in the brain, Perrachione said, it might be possible to refine the reading therapies used for dyslexia.

Read more:

Scientists probe the origins of dyslexia

Video games help dyslexic kids focus

Brain scans predict dyslexics

 
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