Childhood Diseases

Posted by: Racoon | 2013-01-07


midline large pigmented area on abdomen

Dear Prof

Hope you had a refreshing and restful reboot!

It seems as though there is no end to my kids unusual afflictions. We recently noticed that our youngest son (2y4m) has a difference in pigmentation between his left and right side of his abdomen. Basically the whole left side is darker and it is clearly demarcated on the midline. He has no other pigmented areas or any cafe au lait spots. He is very well otherwise, apart from suspected Marie Unna hereditory hypotrichosis (my husband and his mother are have a confirmed diagnosis). His older brother has heterochromia of the scalp hair, but blood kariotyping did not find mosaicism. What I have found so far is sigmented pigmentory anomaly which seems benign, but I would just like to confirm whether we can let it be or whether he needs to see a dermatologist?

Also, what is worrying me is that my eldest son of the 3 has no problems, but the other 2 seem to have some indication of genetical anomalies and I was on fluoxetine with both of them. In literature I have not found much, but it nevertheless worries me...

Expert's Reply



Thank you. It is difficult to be sure about your son's difference in pigmentation of his abdomen. This may be a feature of a condition called cutis marmorata which is also associated with hemihypertrophy in some children. This means that one half of the body appears to grow more rapidly than the other half in infancy and early childhood.This is difficult to spot but fortunately it all evens out later on. It would be best to ask your paediatrician to see your son as a start.
I was unable to find any information linking fluoxetine with congenital disorders, but I must agree that it does appear to be more than a coincidence that two of your children have shown these problems and you were on fluoxetine during your pregnancies with both.

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