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A study of the new test - called microscopic-observation-drug-susceptibility (MODS) - is published in the New England Journal of Medicine.
"In the fight to stop the spread of TB, new diagnostic tools are urgently needed to detect TB and multi drug-resistant TB. MODS is just such a tool. It will change the practice of TB testing in developing countries," said the study senior author, Dr Robert H. Gilman, an international health professor in the Johns Hopkins Bloomberg School of Public Health in the United States.
He and his colleagues collected 3 760 samples of sputum-saliva mixed with respiratory discharge in order to test MODS against the two current gold standard TB tests - the Lowenstein-Jensen culture and the automated mycobacterial culture (using the MBBacT system).
Outperformed current tests
The sensitivity of detecting TB was 97.8 percent for MODS culture, 89 percent for automated mycobacterial culture, and 84 percent for Lowenstein-Jensen culture. The median time for detection of TB was seven days for MODS culture, 13 days for automated mycobacterial culture, and 26 days for Lowenstein-Jensen culture.
The study authors believe MODS will have a major impact on TB in developing countries, where resources are limited. TB kills about two million people each year worldwide. Poor people are disproportionately affected by the disease. – (HealthDayNews)
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A-Z of Tuberculosis
October 2006
