04 February 2011

Cerebral venous thrombosis strikes often

A rare form of stroke that involves veins instead of arteries occurs more often than thought, researchers claim. It's common in women who are pregnant, on oral contraceptives, and in people 45 and younger.


A rare form of stroke that involves veins instead of arteries occurs more often than thought, according to a new American Heart Association/American Stroke Association scientific statement.

This type of stroke - cerebral venous thrombosis (CVT) - is caused by a clot in the dural venous sinuses, which are veins that drain blood from the brain toward the heart. It is most common in women who are pregnant or taking oral contraceptives, and in people age 45 and younger.

The incidence of CVT among pregnant women and those who have recently given birth ranges from one in 2,500 to one in 10,000. The risk is greatest during the third trimester of pregnancy and in the first four weeks after giving birth. Up to 73% of CVT cases occur immediately after childbirth.

But women who've suffered CVT have a low risk of complications during future pregnancies, according to the scientific statement.

Patients with suspected CVT should have blood tests to determine if they have an inherited or acquired factor in the blood that increases the risk of blood clots (prothrombotic factor).

Women on pill should be screened

In addition, patients should be screened for conditions that increase the risk of CVT, such as the use of oral contraceptives, inflammatory disease and infection.

"The most common symptoms of patients with CVT include headaches that progress in severity over days or weeks, and seizures. Some patients may develop a focal neurological deficit (weakness affecting the extremities, double vision, etc.),"  said Dr Gustavo Saposnik, chair of the statement writing group and an assistant professor of medicine at Saint Michael's Hospital, University of Toronto.

Diagnosis of CVT can be challenging. For example, 30 to 40% of patients with CVT may develop an intracranial haemorrhage (bleeding within the skull).

"It's important to distinguish a haemorrhage caused by a ruptured brain artery from those associated with CVT. The mechanisms -- and treatment - of the bleeding are quite different," Saposnik said.

The statement outlined the approach doctors should take to diagnose and manage CVT:

  • Clinical suspicion of CVT.
  • MRI, or alternative imaging technique at hospitals/medical centres with fewer resources.
  • Confirm CVT.
  • Begin anticoagulation therapy (IV Heparin).
  • Continue anticoagulation therapy, lasting three to 12 months to a lifetime.

Other options may be considered in patients who continue to experience neurological deterioration despite medical treatment. These options include surgery to temporarily remove a section of skull to relieve pressure on the brain (hemicraniectomy), or minimally invasive surgery to remove clots in the affected veins (endovascular treatment).

The scientific statement, published in the journal Stroke, is endorsed by a number of organisations, including the American Academy of Neurology and the American Academy of Neurological Surgeons.

(Copyright © 2010 HealthDay. All rights reserved.)


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