Sleep Disorders

02 May 2013

ER visits tied to sleep meds on the rise

There has been a sharp increase in the number of emergency-room visits related to sleep medications, a new study warns.

0

There has been a dramatic increase in the number of emergency-room visits related to sleep medications such as Ambien, according to a new US study.

Adverse reactions to zolpidem  the active ingredient in the sleep aids Ambien, Ambien CR, Edluar and Zolpimist rose almost 220% between 2005 and 2010, researchers from the US Substance Abuse and Mental Health Services Administration (SAMHSA) found.

The study authors concluded that use of these drugs for the short-term treatment of insomnia should be carefully monitored. Zolpidem, which has been approved by the US Food and Drug Administration, has been used safely and effectively by millions of Americans, but adverse reactions to the medication have increased. Most of these cases involved people aged 45 and older, the researchers said.

Potential adverse reactions

"Although short-term sleeping medications can help patients, it is exceedingly important that they be carefully used and monitored," SAMHSA administrator Pamela Hyde said in an agency news release. "Physicians and patients need to be aware of the potential adverse reactions associated with any medication, and work closely together to prevent or quickly address any problems that may arise."

Possible adverse reactions from medications containing zolpidem include:

  • Daytime drowsiness
  • Dizziness
  • Hallucinations
  • Agitation
  • Sleep-walking
  • Drowsiness while driving

After analysing findings from a public health surveillance system that monitors drug-related illnesses and deaths, the researchers found that emergency-room cases involving medications such as Ambien increased sharply from about 6 000 in 2005 to more than 19 000 in 2010.

Reduced dosage recommended

Women were more often affected than men. The findings revealed that during the study time frame, there was a 274% increase in the number of women who went to the emergency room due to a reaction involving zolpidem, compared to a 144% increase among men. In 2010 alone, women accounted for 68% of all trips to the emergency room for an adverse reaction related to zolpidem, the researchers said.

The study authors also noted that adverse reactions to these sleep aids could be worsened when the medication is taken with other substances, such as certain anti-anxiety drugs and narcotic pain relievers.

The SAMHSA report said that in 2010, half of all emergency-room visits related to zolpidem involved its interaction with other drugs. Moreover, 37% of all emergency visits resulted from the combination of these sleep aids and drugs that depress the central nervous system.

In response to the increase in adverse reactions, in January 2013 the FDA required drug manufacturers to cut the recommended dose for women in half. The FDA also recommended that drug companies reduce the dosage for men.

More information

The U.S. National Institutes of Health has more about zolpidem.

Copyright © 2016 HealthDay. All rights reserved.

 

Read Health24’s Comments Policy

Comment on this story
0 comments
Comments have been closed for this article.

Ask the Expert

Sleep disorders expert

Dr Alison Bentley is a general practitioner who has consulted in sleep medicine and sleep disorders, in both adults and children of all ages, for almost 30 years. She also researches and publishes on a number of sleep-related topics both in formal research journals and lay publications including as editor of Sleep Matters, an educational newsletter on sleep disorders for doctors.

Still have a question?

Get free advice from our panel of experts

The information provided does not constitute a diagnosis of your condition. You should consult a medical practitioner or other appropriate health care professional for a physical exmanication, diagnosis and formal advice. Health24 and the expert accept no responsibility or liability for any damage or personal harm you may suffer resulting from making use of this content.

* You must accept our condition

Forum Rules