Pain Centre

Updated 09 February 2017

Painkillers and alcohol make a potent cocktail

Drinking while taking opioids painkillers can interfere with breathing, especially among seniors, a new study finds.

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Drinking alcohol while taking powerful opioid painkillers can trigger a potentially deadly respiratory problem, particularly in seniors, a new study warns.

"Unfortunately, we're seeing more fatalities and people in emergency rooms after having misused or abused legally prescribed opioids, like oxycodone, while having consumed alcohol," said study author Dr Albert Dahan.

Alcohol worsens the effect of opioids 

"Respiratory depression, where breathing becomes very shallow or stops temporarily, is a potentially fatal complication of opioid use. We found alcohol exacerbated the already harmful respiratory effects of opioids," Dahan said.

Dahan is head of the Anaesthesia and Pain Research Unit at Leiden University Medical Centre in the Netherlands.

In the study, the researchers assessed how mixing the opioid painkiller oxycodone and alcohol affected 12 younger volunteers, aged 21 to 28, and 12 older volunteers, aged 66 to 77. None of the participants had taken opioids previously.

Oxycodone, an ingredient in the brand-name drugs OxyContin and Percocet, is widely prescribed to treat chronic pain.

Death by opioid

More than 2 million Americans abuse opioids, according to the US National Institute on Drug Abuse. Every day, 78 people die from opioid overdoses, according to the US Centres for Disease Control and Prevention.

Meanwhile, reports have shown that these deaths often involve other substances such as alcohol, the researchers noted.

The study authors reported that taking just one oxycodone tablet with a modest amount of alcohol increased the risk of respiratory depression.

The older volunteers were more likely than the younger ones to have repeated episodes where they temporarily stopped breathing.

The study was published online in the journal Anaesthesiology.

"We hope to increase awareness regarding the dangers of prescription opioids, the increased danger of the simultaneous use of opioids and alcohol, and that elderly people are at an even greater increased risk of this potentially life-threatening side effect," Dahan said in a journal news release.

"Ultimately, people should know that it is never a good idea to drink alcohol with opioids," he concluded.

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