Meds and you

27 September 2013

The combination of latanoprost and timolol

The combination of latanoprost and timolol is an anti-glaucoma preparation. Anti-glaucoma preparations are drugs that reduce pressure inside the eye.

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The combination of latanoprost and timolol is the active ingredient of Xalacom eye drops (Nappi code: 702983-003).

General information
The combination of latanoprost and timolol is an anti-glaucoma preparation. Anti-glaucoma preparations are drugs that reduce pressure inside the eye.

In South Africa the combination of latanoprost and timolol is registered for the reduction of raised intra-ocular pressure and for the treatment of open-angle glaucoma.

For this medication to be effective, it has to be taken regularly, even if you do not notice an immediate effect.

It should be noted that because this drug may cause visual disturbances and/or dizziness, driving and any hazardous tasks should be avoided until you know how this medication affects you.

This product should not be used if you have soft contact lenses in your eyes.

How does the combination of latanoprost and timolol work?
Latanoprost mimics the effect of a naturally occurring chemical responsible for increasing the outflow of aqueous fluid from the eyeball, thereby reducing pressure within the eye. In addition timolol causes blood vessels in the eye to narrow. By narrowing these blood vessels, less fluid passes through the blood vessel into the eyeball, thereby reducing pressure within the eye further.

Fast facts

Drug schedule: schedule 4
Available as: the combination of latanoprost and timolol is available as eye drops.
What does it do? This combination reduces pressure within the eye.
Overdose risk: high
Dependence risk: low
s the combination of latanoprost and timolol available as a generic? no
Is the combination of latanoprost and timolol available on prescription only? yes

User information

Onset of effect: within 1 hour
Stopping this medicine: do not stop taking this drug without consulting your doctor.
Prolonged use: regular eye examinations are advised.

Special precautions
Consult your doctor before using this drug if:

  • you have or had heart disease
  • you have asthma
  • you have chronic bronchitis
  • you have diabetes
  • you have a slow heart rate (<50 beats per minute)

Pregnancy: avoid. Potential risk to the foetus has been reported. Consult your doctor before use, or if you are planning to fall pregnant.
Breastfeeding: avoid. It is unknown how this medication may affect your baby. Consult your doctor before use.
Porphyria: avoid. It is unknown how this medication may affect your condition. Consult your doctor before use.
Infants and children: this medication is not intended for use in children.
The elderly: caution is advised in the elderly as side effects are more likely to occur.
Alcohol: no special precautions need to be taken.

Possible side effects

 

Side Effect
Frequency
Consult your doctor
 
Common
Rare
Only if severe
In all cases
burning
X
 
X
 
stinging
X
 
X
 
itching
X
 
X
 
blurred vision
X
 
X
 
sensation of having a foreign body in the eye
 
X
X
 
red eye
 
X
 
X
eye pain
 
X
X
 
dry eyes
 
X
X
 
photosensitisation
 
X
X
 
pigmentation changes in eyes
 
X
 
X
eyelash changes – darker, longer, thicker
 
X
 
X
breathing difficulties
 
X
 
X
asthma
 
X
 
X
chest pain
 
X
 
X
skin reactions
 
X
 
X
dizziness
 
X
 
X
corneal disorders
 
X
 
X

Interactions

Drug interactions

 

thiomersal use at least 5 minutes apart to prevent precipitation
dipivefrine additive reduction of intra-ocular pressure
acetazolamide additive reduction of intra-ocular pressure
pilocarpine additive reduction of intra-ocular pressure
reserpine lowering of blood pressure, slow heart rate and dizziness may occur
digoxin increased side effects of digoxin
verapamil increased side effects of verapamil
oral beta-receptor blockers increased risk of side effects with both drugs

Disease interactions
Consult your doctor before using this combination if you have or had heart disease, you have asthma, chronic bronchitis, diabetes or if you have a slow heart rate (<50 beats per minute).

Overdose action
A small overdose is no cause for concern. In case of intentional large overdose, seek emergency medical attention.

Recommended dosage
Adults: 1 drop in affected eye(s) once daily, preferably in the evening.

 

This material is not intended to substitute medical advice, but is for informational purposes only. Please consult a physician for specific treatment and recommendations.

 

 
 

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