Meds and you

Updated 11 February 2013

Teichoplanin

Teichoplanin is a broad-spectrum antibiotic drug indicated for penicillin-allergic patients who cannot receive, or who have failed to respond to penicillins.

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Teichoplanin is the active ingredient of Targocid.

General information

Teichoplanin is a broad-spectrum antibiotic drug indicated for penicillin-allergic patients who cannot receive, or who have failed to respond to penicillins or cephalosporin-antibiotics, and for infections caused by teichoplanin-sensitive organisms that are resistant to other antimicrobial drugs .

It is effectively applied in the treatment of septicaemia, endocarditis (a bacterial infection of the heart lining), inflammation of the bone marrow and adjacent bone as a result of bacterial infection, upper and lower respiratory tract infections, intra-abdominal infections, urinary tract infections and skin, soft tissue and wound infections caused by organisms that are sensitive to teichoplanin.

The use of this antibiotic is reserved for hospital use only.

To reduce the development of drug-resistant bacteria and maintain the effectiveness of teichoplanin and other antibacterial drugs, teichoplanin should be used only to treat or prevent infections that are proven, or strongly suspected to be caused by bacteria.

Hearing loss has occurred in patients receiving teichoplanin. It may be transient or permanent. It has been reported mostly in patients who have been given excessive doses, who have an underlying hearing loss, or who are receiving concomitant therapy with another ototoxic agent – drugs that may cause hearing loss - such as an aminoglycoside antibiotic.

How does teichoplanin work?

It works by interfering with bacterial ability to form cell walls, and therefore the bacteria break up and die.

Fast facts

Drug schedule: schedule 4

Available as: teichoplanin is available as injection

What does it do? Teichoplanin has an antibiotic action.

Overdose risk: medium

Dependence risk: low

Is teichoplanin available as a generic? no

Is teichoplanin available on prescription only? yes

Special precautions

Consult your doctor before using this drug if:

  • you are allergic to any antibiotics
  • you have any history of or existing hearing abnormalities
  • you have kidney or liver disease
  • you are taking any other medication

Pregnancy: avoid. Potential risk to the foetus has been reported. Consult your doctor before use, or if you are planning to fall pregnant.

Breastfeeding: avoid. This medication is passed through breast milk and may affect your baby adversely. Consult your doctor before use.

Porphyria: avoid. It is unknown how this medication may affect your condition. Consult your doctor before use.

Infants and children: s afety and efficacy has not been established in children under three years of age; t his medication should only be used as prescribed by a paediatrician.

The elderly: caution is advised in the elderly and a reduced dose may be needed.

Possible side effects

Side effect

Frequency

Consult your doctor

Common

Rare

Only if severe

In all cases

nausea/vomiting

x

x

diarrhoea

x

x

difficulty breathing/ swallowing

x

x

sin rash/itch

x

x

headache/dizziness

x

x

pain/ inflammation at site of injection

x

x

hearing loss/ ringing in ears

x

x

Interactions

Drug interactions

ciprofloxacin

risk of seizures

warfarin

possible reduced effect of warfarin

drugs that may affect hearing

increased risk of hearing loss

Disease interactions

Consult your doctor before using this drug if you are allergic to any antibiotics, have any hearing disorders. or if you have kidney or liver disease.

Recommended dosage

Adults: 200 - 400mg/day with a maximum daily dose of 800mg given as 2 divided doses.

Children: only as prescribed by a paediatrician.

 

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