Meds and you

30 September 2013

Sulindac

Sulindac is a non-steroidal anti-inflammatory medication.

0

Sulindac is the active ingredient of Adco-Sulindac (Nappi Code: 791113-019).

General Information
Sulindac is a non-steroidal anti-inflammatory medication.

In South Africa it is prescribed to relieve inflammation, swelling, stiffness, pain and fever. It is of particular use in arthritic conditions, including rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and for the treatment of acute gout attacks.

This medication does not cure the underlying condition responsible for pain or inflammation, but simply keeps the symptoms under control.

Mefenamic acid may irritate or even damage your stomach. To reduce this, it is advised to take this medication with food.

This risk increases the longer you take this medication, or if you are also taking corticosteroid medications such as prednisone, anticoagulants (blood thinning medication) such as warfarin, or if you smoke or consume alcohol while being treated with mefenamic acid.

How does sulindac work?
Sulindac blocks the production of the chemical in body that is responsible for pain, swelling and inflammation.

Fast facts

Drug schedule: schedule 3
Available as: sulindac is available as tablets.
What does it do? Sulindac reduces pain and inflammation.
Overdose risk: medium
Dependence risk: low
Is Sulindac available as a generic? yes
Is Sulindac available on prescription only? yes

User information

Onset of effect: within 2 hours
Duration of action: up to 12 hours
Dietary advice: sulindac should be taken with food to prevent gastrointestinal irritation.
Stopping this medicine: this medication can be safely stopped if used for short-term treatment; if your doctor prescribed it for longer periods of time you should consult your prescriber before discontinuing this drug.
Prolonged use: prolonged use is more likely to cause side effects.

Special precautions
Consult your doctor before using this drug if:

Pregnancy: avoid. Potential risk to the foetus has been reported. Consult your doctor before use, or if you are planning to fall pregnant.
Breastfeeding: avoid. It is unknown how this medication may affect your baby. Consult your doctor before use.
Porphyria: sulindac is considered safe.
Infants and children: this drug is not intended for use in children.
The elderly: caution is advised in the elderly as side effects are more likely.
Driving and hazardous work: caution is advised as use of this medication may lead to dizziness, light-headedness and/or sedation. Avoid such activities until you know how this medication affects you.
Alcohol: avoid concomitant use of alcohol with this medication as it may worsen stomach irritation.

Possible side effects

Side Effect
Frequency
Consult your doctor

Common
Rare
Only if severe
In all cases
abdominal pain
X

X

nausea/vomiting

X
X

constipation

X
X

heartburn
X

X

headache

X
X

drowsiness/dizziness


X

visual disturbances

X

X
difficulty swallowing/breathing

X

X
swelling of lips, face or tongue

X

X
yellow tinge to skin/eyes

X

X
rash/itch

X

X
fever/chills

X

X
convulsions

X

X
blood in vomit

X

X
dark tarry stools

X

X

Interactions

Drug interactions

blood pressure medication reduced pressure lowering effect
alcohol potential gastrointestinal symptoms
dimethyl Sulfoxide reduced effect of sulindac
warfarin risk of bleeding
asthma medication reduced effect of asthma medication; risk of asthma attack
cardiac glycosides, digoxin risk that heart failure may be more severe
corticosteroids potential gastrointestinal symptoms
ciclosporin potential sulindac toxicity
methotrexate potential methotrexate toxicity
diuretics potential risk of kidney damage
blood glucose lowering drugs risk of prolonged low blood sugar
baclofen potential baclofen toxicity
other NSAID’s potential risk of gastrointestinal bleeding
probenecid risk of sulindac toxicity
quionolone antibiotics risk of seizures
tacrolimus increased risk of kidney damage
zidovudine increased risk of zidovudine toxicity

Disease interactions
Consult your doctor before using this drug if you have asthma, liver or kidney disease, epilepsy, Parkinson’s disease, a stomach ulcer, a bleeding disorder, or if you have been diagnosed with a psychiatric disorder.

Overdose action
A small overdose is no cause for concern. In case of intentional large overdose seek emergency medical attention.

Recommended dosage
Adults: oral, 100-200 mg twice daily

This material is not intended to substitute medical advice, but is for informational purposes only. Please consult a physician for specific treatment and recommendations.
 
 

Read Health24’s Comments Policy

Comment on this story
0 comments
Comments have been closed for this article.