Silymarin is the active ingredient of Legalon 70 tabs (Nappi code:
Silymarin is a hepatoprotector. Hepatoprotectors include a wide variety of
nutrients and chemicals that seem to be able to protect the liver from toxic
In South Africa silymarin is registered for the treatment of alcohol-induced
This medication does not cure the underlying condition, but simply keeps the
symptoms under control. For is to be effective, it has to be taken regularly,
even if you do not notice an immediate effect.
It is advised not to discontinue treatment before the recommended course has
How does silymarin work?
In animal experiments, silymarin (derived from a plant source) has been shown
to possess an antihepatotoxic action against various liver cell toxins as a
result of anti-oxidant activity.
Drug schedule: schedule 3
Available as: silymarin is
available as tablets.
What does it do? Silymarin protects the liver
against various liver cell toxins.
Overdose risk: low
Is silymarin available as a generic? no
silymarin available on prescription only? yes
Onset of effect: it may take several weeks to observe the full benefit
of this product.
Stopping this medicine: complete the course as
directed by your doctor.
Consult your doctor before using this drug if:
- you had an allergic reaction to silymarin before
Pregnancy: safe for short-term use (not exceeding 3 weeks)
Breastfeeding: avoid. It is unknown how this medication may
affect your baby. Consult your doctor before use.
Porphyria: avoid. It
is unknown how this medication may affect your condition. Consult your doctor
Alcohol: avoid concomitant use of alcohol with this
Possible side effects
Consult your doctor
Only if severe
In all cases
No interactions are known.
A small overdose is no cause for concern. In case of intentional large
overdose, seek emergency medical attention.
Adults, oral: 1 - 2 tablets three times daily.
(This material is not intended to substitute medical advice, but is for
informational purposes only. Please consult a physician for specific treatment