Meds and you

30 September 2013

Propantheline

Propantheline is an anti-spasmodic. Anti-spasmodics are agents that relieve smooth muscle spasms or cramps.

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Propantheline is the active ingredient of Pro-Banthine (Nappi Code: 757136-028).

General information
Propantheline is an anti-spasmodic. Anti-spasmodics are agents that relieve smooth muscle spasms or cramps.

Propantheline is used for the relief of gastro-intestinal muscle spasms and for the suppression of gastric acid secretion.

In South Africa it is registered for the following indications:

  • gastro-intestinal disorders that may include gastro-intestinal muscle spasms (i.e. gastritis, diverticulitis, cholecystitis and pancreatitis)

  • irritable bowel syndrome (a condition in which the colon muscle contracts more readily causing abdominal pain and cramps, excess gas, bloating and a change in bowel habits)

  • peptic ulcers (adjunctive treatment)

  • bedwetting

  • involuntary loss of bladder control

Propantheline is also used for the treatment of excessive perspiration in the face, hands, and feet.

It should be noted that this drug does not cure the underlying condition, but simply keeps the symptoms under control. For it to be effective it has to be taken regularly.

How does propantheline work?
Propantheline has a relaxing effect on gastro-intestinal smooth muscles, thereby reducing cramps.

Fast facts Drug schedule: schedule 2
Available as: propantheline is available as tablets.
What does it do? Propantheline relieves gastro-intestinal muscle spasms, reduces the secretion of gastric acid, and reduces excessive sweating.
Overdose risk: medium
Dependence risk: low
Is propantheline available as a generic? no
Is propantheline available on prescription only? no

User information Onset of effect: the onset of action depends on the condition being treated.
Duration of action: up to 8 hours
Stopping this medicine: do not stop using propantheline without consulting your doctor. Initial symptoms may return with premature stoppage. Special precautions
Consult your doctor before using this drug if:

  • you have glaucoma

  • you have been diagnosed with an obstructive gastro-intestinal or urinary disease

  • you have myasthenia gravis

  • you have difficulty urinating

  • you have liver or kidney disease

  • you have a heart problem

  • you have been diagnosed with ulcerative colitis

  • you have prostate problems

  • you are taking other medication

Pregnancy: avoid. It is unknown how this medication may affect your baby. Consult your doctor before using this drug, or if you are planning to fall pregnant.
Breastfeeding: avoid. It is unknown how this medication may affect your baby. Consult your doctor before use.
Porphyria: this medication is safe for use.
Infants and children: this medication is not intended for use in children.
The elderly: caution is advised in the elderly as likelihood of adverse effects in increased.
Driving and hazardous work: caution is advised as use of this medication may lead to dizziness, light-headedness and/or sedation. Avoid such activities until you know how this medication affects you.
Alcohol: avoid concomitant use of alcohol with this medication.

Possible side effects

Side Effect
Frequency
Consult your doctor

Common
Rare
Only if severe
In all cases
constipation
X

X

nausea/vomiting

X
X

dry mouth
X

X

blurred vision
X

X

urinary hesitancy

X
X

dizziness

X
X

pain in the eye

X

X
change in mood

X

X
skin rash/itch

X

X
heart palpitations

X

X

Interactions

digoxin increased risk of digoxin toxicity
hydrochlorothiazide increased effect of hydrochlorothiazide
paracetamol possible delayed effect of paracetamol
ketokonazole reduced absorption of ketokonazole into the body

Many other drugs may interact with propantheline. It is important to consult your doctor or pharmacist before combining any drug with propantheline.

Disease interactions
Consult your doctor before using this drug if you have glaucoma, you have been diagnosed with an obstructive gastro-intestinal or urinary disease, you have myasthenia gravis, difficulty urinating, liver or kidney disease, a heart problem, if you have been diagnosed with ulcerative colitis or if you have prostate problems.

Overdose action
An overdose of this medication can be fatal. Seek immediate emergency medical attention.

Recommended dosage
Adults, oral: 45-90 mg daily in 4 divided doses

This material is not intended to substitute medical advice, but is for informational purposes only. Please consult a physician for specific treatment and recommendations.
 
 

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