Prochlorperazine is the active ingredient of Mitil tablets (Nappi Code:
744182-026), Scripto-matic tablets (Nappi Code: 762849-126), Stemetil tablets
(Nappi Code: 766542-009/017), Stemetil supps (Nappi Code: 766518-019,
766526-003) and Stemetil injection (Nappi Code: 766461-009).
Prochlorperazine is an anti-emetic.
Anti-emetics are drugs that are used to treat and prevent nausea and
In South Africa prochlorperazine is registered for the symptomatic relief of
nausea and vomiting and for the management of vertigo, schizophrenia, psychosis
and minor emotional disturbances.
Prochlorperazine is also used as an adjunctive treatment of migraine.
It should be noted that this drug does not cure the underlying condition, but
simply keeps the symptoms under control.
Because prochlorperazine may cause dizziness, light-headedness and/or
sedation, driving and any hazardous tasks should be avoided until you know how
this medication affects you.
How does prochlorperazine work?
Fast facts Drug schedule: schedule 5
prochlorperazine is available as tablets, injections or
What does it do? Prochlorperazine prevents and relieves
nausea and vomiting.
Overdose risk: medium
Is prochlorperazine available as a generic? yes
prochlorperazine available on prescription only? yes
Onset of effect: 20-60
Duration of action: up to 6 hours
medicine: if you are taking this drug for short-term use in can be safely
stopped when no longer needed. In case of long term use you should consult your
Prolonged use: prolonged use is not recommended. The
patient may develop irreversible tardive dyskineasia, jaundice or pigmentation
of the eyes.
Consult your doctor before using this drug
- you have liver or kidney disease
- you have cardiovascular disease
- you have a medical condition affecting your breathing
- you have epilepsy
- you have glaucoma
- you have prostate problems
- you have Parkinson's Disease
- you have a thyroid disorder
- you have been diagnosed with phaeochromocytoma
- you have a history of jaundice
- you are taking any other medication
Pregnancy: avoid. Potential risk to the foetus has been reported.
Consult your doctor before use, or if you are planning to fall
Breastfeeding: avoid. This medication is passed through
breast milk and may affect your baby adversely. Consult your doctor before
Porphyria: this medication is safe to use.
children: this medication is not intended for use in children who weigh less
than 10 kg or who are younger than 10 years.
The elderly: caution is
advised in the elderly as there is an increased likelihood of adverse
Driving and hazardous work: caution is advised as use of this
medication may lead to dizziness, light-headedness and/or sedation. Avoid such
activities until you know how this medication affects you.
avoid concomitant use of alcohol with this medication.
Possible side effects
|antacids that contains aluminium or magnesium
||reduced effect of prochlorperazine|
|atropine or other ant cholinergic drugs
||enhanced risk of anticholinergic adverse effects which may include dry
mouth, constipation or urinary retention|
|blood pressure medication
||increased risk of a drop in blood pressure|
|drugs for Parkinsonism
||worsening of Parkinsonism symptoms|
||reduced effect of both prochlorperazine and phenobarbital|
|sedative drugs (alcohol, benzodiazepines, antihistamines
||increased CNS suppression and CNS effects|
||reduced levels of prochlorperazine in body|
||increased risk of toxicity of both prochlorperazine and
||reduces effect of these drugs|
||risk of abnormal heart rhythms|
||increased risk of toxicity of both prochlorperazine and the
Consult your doctor before using this drug if
you have liver or kidey disease, cardiovascular disease, any medical condition
affecting your breathing, if you have epilepsy, glaucoma, prostate problems, a
history of hepatitis, Parkinson's disease, a thyroid disorder, or if you have
been diagnosed with phaeochromocytoma or if you have a history of jaundice.
A small overdose is no cause for concern. In case
of intentional large overdose seek emergency medical attention.
Adults: oral, 15-40 mg/day in 3-4 divided
doses with a maximum daily dose of 100 mg/day
This material is not intended to substitute medical advice, but is
for informational purposes only. Please consult a physician for specific
treatment and recommendations.