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27 September 2013

Piretanide

Piretanide is a diuretic. Diuretics are drugs that increase the production of urine, thereby removing excess water from the body.

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Piretanide is the active ingredient of Arelix tablets (Nappi Code: 807796-018, 807818-003).

General information
Piretanide is a diuretic. Diuretics are drugs that increase the production of urine, thereby removing excess water from the body.

In South Africa piretanide is registered for the treatment of oedema (swelling) i.e. of cardiac, hepatic, or pulmonary origin. It is also indicated for the treatment of mild to moderately high blood pressure

For it to be effective piretanide has to be taken regularly, even if you do not notice an immediate effect. Do not discontinue this medication without consulting your doctor, as symptoms may recur with premature stoppage.

The use of this drug may lead to an excessive loss of potassium from the body. Potassium supplements are usually required.

How does piretanide work?
Piretanide lowers the amount of excess salt and water in the body by increasing the flow of urine.

Fast facts

Drug schedule: schedule 3
Available as: piretanide is available as tablets.
What does it do? Piretanide increases the flow of urine from the body.
Overdose risk: low
Dependence risk: low
Is piretanide available as a generic? no
Is piretanide available on prescription only? yes

User information

Dietary advice: the use of this drug may lead to an excessive loss of potassium from the body. Potassium supplements are usually required.
Stopping this medicine: do not discontinue this medication without consulting your doctor as symptoms may recur with premature stoppage.
Prolonged use: long term use may be associated with a loss of salt from the body which may cause muscle cramps, weakness, etc. Your doctor may need to keep an eye on this.

Special precautions
Consult your doctor before using this drug if:

  • you have gout

  • you have kidney or liver disease

  • if you are dehydrated

  • if you have a condition that makes urination difficult, i.e. prostate trouble

  • you have diabetes

Pregnancy: avoid. Potential risk to the foetus has been reported. Consult your doctor before use, or if you are planning to fall pregnant.
Breastfeeding: avoid. It is unknown how this medication may affect your baby. Consult your doctor before use.
Porphyria: avoid. It is unknown how this medication may affect your condition. Consult your doctor before use.
Infants and children: this medication is not intended for use in children.
The elderly: caution is advised as the likelihood of side-effects is increased.
Driving and hazardous work:caution is advised as use of this medication may lead to dizziness, light headedness and/or sedation. Avoid such activities until you know how this medication affects you.
Alcohol: avoid concomitant use of alcohol with this medication as it may increase risk of dehydration.

Possible side effects

Side Effect
Frequency
Consult your doctor

Common
Rare
Only if severe
In all cases
dizziness
X

X

headache
X

X

low blood pressure
X

X

muscle cramps

X
X

dry mouth

X
X

rash

X

X
unusual tiredness/weakness

X

X
pain in joints

X

X
irregular heart beat

X

X
hearing impairment

X

X

Interactions

Drug interactions

non-steroidal anti-inflammatory may reduce the drug’s diuretic and blood pressure
drugs (NSAID's) e.g. Ibuprofen lowering effect
aminoglycoside antibiotics increased risk of hearing loss
amphotericin B increased risk of low potassium/magnesium levels
vancomycin increased risk of hearing loss
corticosteroids increased risk of low potassium/magnesium levels
digoxin increased risk of digoxin toxicity
halofantrine increase risk of heart rhythm disturbance
lithium increased risk of lithium toxicity
probenecid increased diuretic effect
bumetanide, Furosemide increased diuretic effect
captopril decreased excretion of piretanide; increased risk of piretanide side effects

Disease interactions
Consult your doctor before using this drug if you have kidney or liver disease, are dehydrated, have a condition that makes urination difficult, have diabetes or if you have gout.

Overdose action
A small overdose is no cause for concern. In case of intentional large overdose seek emergency medical attention.

Recommended dosage
Dose: oral, 3-12 mg/day with a maximum of 30 mg

This material is not intended to substitute medical advice, but is for informational purposes only. Please consult a physician for specific treatment and recommendations.
 
 
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