Meds and you

27 September 2013

Olsalazine

Olsalazine is an intestinal anti-inflammatory agent.

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Olsalazine is the active ingredient of Dipentum Capsules (Nappi Code: 792519-019).

General information
Olsalazine is an intestinal anti-inflammatory agent.

In South Africa olsalazine is registered for the treatment of ulcerative colitis, a serious intestinal inflammatory disorder that causes ulcers and irritation in the inner lining of the colon and rectum.

This drug does not cure the underlying condition, but simply keeps the symptoms under control. For olsalazine to be effective it has to be taken regularly, even if you do not notice an immediate effect.

How does olsalazine work?
It reduces the inflammation in the intestine, which in turn reduces the symptoms of the disease.

Fast facts

Drug schedule: schedule 3
Available as: olsalazine is available as capsules.
What does it do? Olsalazine has an anti-inflammatory action.
Overdose risk: low
Dependence risk: low
Is olsalazine available as a generic? no
Is olsalazine available on prescription only? yes

User information Onset of effect: it may take several days for the full effect to be seen.
Duration of action: up to 12 hours
Dietary advice: olsalazine should best be taken with food.
Stopping this medicine: do not withdraw treatment abruptly as this may cause a return of symptoms. Consult you prescriber before discontinuing treatment.
Prolonged use: there is an increased risk of adverse effects with prolonged use.

Special precautions
Consult your doctor before using this drug if:

  • you are allergic to aspirin

  • you have liver or kidney disease

  • you are taking other medication

Pregnancy: avoid. Potential risk to the foetus has been reported. Consult your doctor before use, or if you are planning to fall pregnant.
Breastfeeding: avoid. This medication is passed through breast milk and may affect your baby adversely. Consult your doctor before use.
Porphyria: avoid. This medication may cause serious adverse effects. Consult your doctor before use.
Infants and children: this medication is not intended for use in children under the age of 15 years.
The elderly: no special precautions need to be taken.
Driving and hazardous work: no special precautions need to be taken.
Alcohol: no special precautions need to be taken.

Possible side effects

Side Effect
Frequency
Consult your doctor

Common
Rare
Only if severe
In all cases
nausea and vomiting
X

X

diarrhoea
X

X

loss of appetite
X

X

abdominal pain
X

X

headache

X
X

joint pain

X
X

skin rash

X

X
fever

X

X
sore throat

X

X
abnormal bruising/bleeding

X

X

Interactions

antacids premature release of olsalazine
azathioprine; Mercaptopurine increased risk of azathioprine / mercaptopurine toxicity
warfarin reduced effect of warfarin
lactulose reduced olsalazine release

Disease interactions
Consult your doctor before using this drug if you are allergic to, or if you have liver or kidney disease.

Overdose action
A small overdose is no cause for concern. In case of intentional large overdose seek emergency medical attention.

Recommended dosage
Adults: oral, 0.5-3 g/day in divided doses

This material is not intended to substitute medical advice, but is for informational purposes only. Please consult a physician for specific treatment and recommendations.
 
 

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