Meds and you

27 September 2013

Monosulfiram

Monosulfiram is an ectoparasiticide. Ectoparasiticides are drugs that are used to treat ectoparasitic infections.

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(Also known as sulfiram, tetraethylthiuram monosulphide)

Monosulfiram is the active ingredient of Tetmosol (Nappi Code: 770116-019).

General information
Monosulfiram is an ectoparasiticide. Ectoparasiticides are drugs that are used to treat ectoparasitic infections.

Ectoparasites - parasites found on the surface of the body - include scabies, a skin disorder caused by a mite that burrows into the skin and produces an intense, itchy rash, and pediculosis, better known as a lice infection with either the head, pubic or body louse.

In South Africa monosulfiram is registered for the prevention and treatment of scabies.

It is especially useful in controlling scabies outbreaks in boarding schools, hospitals and other closed communities.

If systemically absorbed, this product may react adversely with alcohol, causing nausea, vomiting and headache. Abstain from using alcohol for 48 hours before and after application.

How does monosulfiram work?
Monosulfiram have been shown to readily kill the scabies mite, sarcoptes scabiei.

Fast facts

Drug schedule: unscheduled
Available as: this medication is available as an emulsion.
What does it do? Monosulfiram kills parasites.
Overdose risk: low
Dependence risk: low
Is monosulfiram available as a generic? yes
Is monosulfiram available on prescription only? no

Special precautions
Consult your doctor before using this drug if:

  • you have sensitive skin

  • you have had previous allergic reactions with this product

  • you are pregnant or breastfeeding

Pregnancy: avoid. It is unknown how this medication may affect your baby. Consult your doctor before using this drug, or if you are planning to fall pregnant.
Breastfeeding: avoid. It is unknown how this medication may affect your baby. Consult your doctor before use.
Porphyria: avoid. It is unknown how this medication may affect your condition. Consult your doctor before use.
Infants and children: no special precautions need to be taken.
The elderly: no special precautions need to be taken.
Driving and hazardous work: no special precautions need to be taken.
Alcohol: abstain from using alcohol before and for at least 48 hours after the application of this soap.

Possible side effects

Side Effect
Frequency
Consult your doctor

Common
Rare
Only if severe
In all cases
rash

X
X

nausea/vomiting when taking alcohol

X
X

Interactions
No interactions are known.

Disease interactions
Consult your doctor before using this drug if you are pregnant or breastfeeding.

Overdose action
A small overdose is no cause for concern. If ingested, seek emergency medical attention.

Recommended dosage
Monosulfiram is used in place of ordinary toilet soap. Ideally, the person should bathe in hot water and soap themselves liberally with the soap paying particular attention to the folded areas of the skin. After bathing, the body should be allowed to dry naturally or dried with a towel using a 'blotting' action. The soap should be used daily for as long as the danger of infection remains.

This material is not intended to substitute medical advice, but is for informational purposes only. Please consult a physician for specific treatment and recommendations.
 
 

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