Meds and you

27 September 2013

Miconazole

Miconazole is an antimycotic. Antimycotics are drugs that destroy or prevent the growth of fungi. An antimycotic drug is thus an antifungal drug.

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Miconazole is the active ingredient of Dermax (Nappi Code: 707299-001), Lamisil Tabs (Nappi Code: 842087-001 & 792713-001), Merck-Terbinafine (Nappi Code: 705114-001), Nafin 250 (Nappi Code: 706553-001), Terbane (Nappi Code: 706757-001), Terbicil (Nappi Code: 705430-001), Lamisil cream (Nappi Code: 792705- 017/009), Lamisil spray (Nappi Code: 703033-001 & , 836486), Lamisil Dermgel (Nappi Code: 880892-005) and Terbicil Cream (Nappi Code: 706073- 001/002).

Miconazole is also one of multiple active ingredients found in Daktacort (Nappi Code: 717266-001).

General information
Miconazole is an antimycotic. Antimycotics are drugs that destroy or prevent the growth of fungi. An antimycotic drug is thus an antifungal drug.

In South Africa miconazole is registered for the treatment of fungal infections of the mouth, throat and skin.

Miconazole oral gel can also be taken to treat fungal infections of the stomach or intestines.

Systemic absorption of miconazole after topical application is very low, but caution is still advised in patients being treated with warfarin (see interactions).

Although miconazole also has some antibacterial action, it is only effective in treating topical fungal infections and will not be effective in treating bacterial infections.

Treatment with miconazole should be continued for two days after the symptoms have cleared up to ensure the infection is fully treated and thus help prevent it coming back.

How does miconazole work?
Miconazole inhibits the manufacturing of substances vital for fungal membrane stability and cell development.

Fast facts

Drug schedule: schedule 2, 4
Available as: miconazole is available as topical, vaginal and oral applications.
What does it do? Miconazole destroys or prevents the growth of fungi.
Overdose risk: low
Dependence risk: low
Is Miconazole available as a generic? yes
Is Miconazole available on prescription only? yes

User information

Onset of effect: up to 3 days
Duration of action: up to 12 hours
Stopping this medicine: Do not stop taking miconazole without consulting your doctor. If you stop taking this medicine too soon, your symptoms may return.

Special precautions
Consult your doctor before using this drug if:

  • you have a liver disease

  • you have porphyria

  • you are taking other antifungal medication

Pregnancy: avoid. It is unknown how this medication may affect your baby. Consult your doctor before using this drug, or if you are planning to fall pregnant.
Breastfeeding: avoid. It is unknown how this medication may affect your baby. Consult your doctor before use.
Porphyria: avoid. This medication may cause serious adverse effects. Consult your doctor before use.
Infants and children: a reduced dose of the oral gel is needed in young children.
The elderly: no special precautions need to be taken.
Driving and hazardous work: no special precautions need to be taken.
Alcohol: no special precautions need to be taken.

Possible side effects

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Side Effect

Frequency
Consult your doctor

Common
Rare
Only if severe
In all cases

local irritation

X
X

diarrhoea

X
X

nausea/vomiting

X
X

Interactions

gliclazide, glibenclamide, tolbutamide blood sugar may fall to dangerously low levels
phenytoin risk of phenytoin toxicity
terfenadine life-threatening heart rhythm disturbances may develop
warfarin risk of bleeding

Disease interactions
Consult your doctor before using this drug if you have a liver disease or if you have porphyria.

Overdose action
A small overdose is no cause for concern. In case of intentional large overdose seek emergency medical attention.

This material is not intended to substitute medical advice, but is for informational purposes only. Please consult a physician for specific treatment and recommendations.
 
 

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