Meds and you

27 September 2013

Mebendazole

Mebendazole is an antihelmintic drug. Antihelmintic drugs are drugs that are used in the treatment of worm infestations.

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Mebendazole is the active ingredient of Adco-Wormex tabs (Nappi Code: 703063-003), Adco-Wormex susptabs (Nappi Code: 703064-003), Adco-Wormex SD tabs (Nappi Code: 704656-001), Cipex Susp (Nappi Code: 828297-002), Cipex Tabs (Nappi Code: 828227-008), D-Worm Chew Tab (Nappi Code: 795607-008), D-Worm SD Tab (Nappi Code: 833894-005), Ridworm Susp (Nappi Code: 702513-002), Ridworm Tabs (Nappi Code: 702513-003), Vermox tabs (Nappi Code: 775614-009), Vermox susp (Nappi Code: 775606-006), Vermox 500 (Nappi Code: 807524-018), Vermox SD Susp (Nappi Code: 881546-003), Wormgo tabs (Nappi Code: 810533-006), Wormstop tabs (Nappi Code: 845671-006), Wormstop susp (Nappi Code: 845698-001) and Wormstop 500 (Nappi Code: 845701-002).

General information
Mebendazole is an antihelmintic drug. Antihelmintic drugs are drugs that are used in the treatment of worm infestations.

In South Africa mebendazole is registered for the treatment of roundworm, hookworm, pinworm, whipworm and strongyloides stercoralis, a human parasitic roundworm causing the disease of strongyloidiasis.

Mebendazole is hardly absorbed into the body and adverse effects are minimal and usually self-limiting.

To avoid re-infestation it is advised to wash bedding and all clothing in warm water in conjunction with mebendazole treatment.

How does mebendazole work? Mebendazole blocks glucose uptake by susceptible worm species, thereby depleting the energy level required for survival. Due to diminished energy production, the parasite is immobilised and eventually dies.

Fast facts

Drug schedule: schedule 2
Available as: mebendazole is available as tablets and syrup.
What does it do? Mebendazole is used in the treatment of worm infestations.
Overdose risk: medium
Dependence risk: low
Is mebendazole available as a generic? yes
Is mebendazole available on prescription only? no

User information Stopping this medicine: do not stop taking this medication before the prescribed course has been completed.

Special precautions
Consult your doctor before using this drug if:

  • you are pregnant or breastfeeding

  • it is to be given to children under the age of 2

  • you have a liver disease

  • you have ulcerative colitis

  • you have Chrohn's disease

Pregnancy: avoid. Potential risk to the foetus has been reported. Consult your doctor before use, or if you are planning to fall pregnant.
Breastfeeding: avoid. It is unknown how this medication may affect your baby. Consult your doctor before use.
Porphyria: avoid. It is unknown how this medication may affect your condition. Consult your doctor before use.
Infants and children: this medication is not intended for use in children under the age of 2
The elderly: no special precautions need to be taken.
Driving and hazardous work: caution is advised as use of this medication may lead to dizziness, light-headedness and/or sedation. Avoid such activities until you know how this medication affects you.
Alcohol: no special precautions need to be taken.

Possible side effects

Side Effect
Frequency
Consult your doctor

Common
Rare
Only if severe
In all cases
abdominal pain
X

X

diarrhoea
X

X

nausea/vomitting

X
X

headache

X
X

fever

X

X
itching skin

X

X
drowsiness/dizziness

X

X
swelling

X

X
weakness

X

X

Interactions

cimetidine increased risk of mebendazole toxicity
carbamazepine decreased effect of mebendazole
phenytoin decreased effect of mebendazole

Overdose action
A small overdose is no cause for concern. In case of intentional large overdose, seek emergency medical attention.

Recommended dosage
Adults: Oral, 100 mg twice daily or 500 mg as a single dose

This material is not intended to substitute medical advice, but is for informational purposes only. Please consult a physician for specific treatment and recommendations.
 
 

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