Meds and you

Updated 11 February 2013

Lornoxicam

Lornoxicam is a non-steroidal anti-inflammatory medication. It is prescribed to relieve inflammation, swelling and stiffness, and is an effective pain killer.

1

Lornoxicam is the active ingredient of Xefo.

General information

Lornoxicam is a non-steroidal anti-inflammatory medication. It is prescribed to relieve inflammation, swelling and stiffness, and is an effective pain killer. It is of particular use for arthritic conditions, muscle injury and broad spectrum pain relief.

This medication does not cure the underlying condition responsible for the inflammatory reaction, but keeps the symptoms under control.

Lornoxicam may irritate or even damage your stomach. This risk increase the longer you take this medication, or if you are also taking corticosteroid medications such as prednisone, anticoagulants (blood thinning medication) such as warfarin, or if you smoke or consume alcohol while being treated with lornoxicam. To reduce this, it is advised to take it with food.

It has been reported that people who take non-steroidal anti-inflammatory medications may have an increased risk of heart attack or a stroke. This risk may be higher if you take these medications over a prolonged period of time. Tell your doctor if you have or have had heart disease, a heart attack, or a stroke.

How does it work?

Lornoxicam blocks the production of chemicals in the body that are responsible for pain, swelling and inflammation.

Fast facts

Drug schedule: Schedule 3

Available as: Tablets and injection.

What does it do? Lornoxicam reduces pain and inflammation

Overdose risk: Medium

Dependency risk: Low

Available as a generic? No

Available on prescription only? Yes

User information

Onset of effect: Within 1 hour.

Duration of action: Up to 24 hours.

Dietary advice: Lornoxicam should be taken with a meal to minimise gastrointestinal irritation.

Stopping this medicine: Unless your doctor has prescribed Lornoxicam for long-term use, it can be safely stopped when no longer needed.

Prolonged use: The likelihood of adverse effects increases with prolonged use. Your doctor may perform periodic liver and kidney function tests, while also examining you for possible gastrointestinal damage.

Special precautions

Consult your doctor before using this drug if:

  • you are allergic to any other non-steroidal anti-inflammatory drug or
  • aspirin
  • you have asthma
  • you have a stomach ulcer or gastric reflux
  • you have liver or kidney disease
  • you have heart disease, or have had a stroke or heart attack
  • you have a bleeding disorder
  • you are taking other medication

Pregnancy: Avoid. Potential risk to the foetus has been reported. Consult your doctor before use, or if you are planning to fall pregnant

Breastfeeding: Avoid. This medication is passed through breast milk and may affect your baby adversely. Consult your doctor before use.

Porphyria: Avoid. It is unknown how this medication may affect your condition. Consult your doctor before use.

Infants and children: This medication is not intended for use in children.

Elderly: Caution is advised in the elderly as side effects may be more likely. The dose may need to be adjusted.

Driving and hazardous work: Caution is advised as use of this medication may lead to dizziness, light-headedness and/or sedation. Avoid such activities until you know how this medication affects you.

Alcohol: Avoid concomitant use of alcohol with this medication as it may worsen stomach irritation

Possible side effects

Side effect

Frequency

Consult your doctor

Common

Rare

Only if severe

In all cases

Abdominal pain

x

x

Diarrhoea

x

x

Nausea

x

x

Headache

x

x

Dizziness

x

x

Drowsiness

x

x

Depression

x

x

Swelling (feet/ ankles)

x

x

Rash/ itch

x

x

Difficulty breathing

x

x

Blood in vomit

x

Dark tarry stools

x

x

Heart palpitations

x

x

Interactions:

Drug interactions:

Blood pressure medication

Reduced pressure lowering effect

Alcohol

Potential gastrointestinal symptoms

Warfarin

Risk of bleeding

Asthma medication

Reduced effect of asthma medication; risk of asthma attack

Cardiac glycosides, digoxin

Risk that heart failure may be more severe

Corticosteroids

Potential gastrointestinal symptoms

Ciclosporin

Potential Lornoxicam toxicity

Cholestyramine

Reduced effect of Lornoxicam

Methotrexate

Potential methotrexate toxicity

Diuretics

Potential risk of kidney damage

Blood glucose lowering drugs

Risk of prolonged low blood sugar

Baclofen

Potential baclofen toxicity

Other NSAID's

Potential risk of gastrointestinal bleeding

Probenecid

Risk of Lornoxicam toxicity

Quionolone antibiotics

Risk of seizures

Tacrolimus

Increased risk of kidney damage

Zidovudine

Increased risk of zidovudine toxicity

Disease interactions

Consult your doctor before using this drug if you have asthma, a stomach ulcer, a bleeding disorder, you are taking blood thinning medication, or if you are allergic to aspirin or any other medication.

Overdose action

A small overdose is no cause for concern. In case of intentional large overdose, seek emergency medical attention.

Recommended dosage

Adults: 8-16mg/day in 2-3 divided doses.

This material is not intended to substitute medical advice, but is for informational purposes only. Please consult a physician for specific treatment and recommendations.

 

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