Meds and you

Updated 11 February 2013

Ketoprofen

Ketoprofen is a non-steroidal anti-inflammatory medication. It is prescribed to relieve inflammation, swelling and stiffness, and is an effective pain killer.

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Ketoprofen is the active ingredient of Fastum gel, Ketoflam SR and Oruvail.

General Information

Ketoprofen is a non-steroidal anti-inflammatory medication. It is prescribed to relieve inflammation, swelling and stiffness, and is an effective pain killer. It is of particular use in arthritic conditions, menstrual pain and discomfort, acute attacks of gout and for broad spectrum pain relief.

This medication does not cure the underlying condition responsible for pain or inflammation, but simply keeps the symptoms under control.

Ketoprofen may irritate or even damage your stomach. To reduce this problem, one is advised to take this medication with food.

This risk increases the longer you take this medication, or if you are also taking corticosteroid medications such as prednisone; anticoagulants (blood thinning medication) such as warfarin; or if you smoke or consume alcohol while being treated with ketoprofen.

How does ketoprofen work?

Ketoprofen blocks the production of chemicals in the body that are responsible for pain, fever, swelling and inflammation.

Fast facts

Drug schedule: Schedule 2, 3

Available as: Ketoprofen is available as tablets and as a gel.

What does it do? Ketoprofen reduces pain, and inflammation

Overdose risk: Medium

Dependence risk: Low

Is ketoprofen available as a generic ? Yes

Is ketoprofen available on prescription only? No

User information

Onset of effect: Within 2 hours

Duration of action: Up to 8 hours

Dietary advice: Ketoprofen should be taken with a meal to minimise gastrointestinal irritation.

Stopping this medicine: If prescribed for long-term use it is advised to keep using ketoprofen as prescribed by your doctor. Do not discontinue use before consulting your prescriber. The gel can be safely stopped when no longer needed.

Prolonged use: The likelihood of adverse effects increases with prolonged use. Your doctor may perform periodic liver and kidney function tests, while also examining you for possible gastrointestinal damage.

Special precautions

Consult your doctor before using this drug if:

  • You have asthma
  • You have a kidney or liver disease
  • You have a stomach ulcer
  • You have a bleeding disorder
  • You have heart disease
  • You are taking blood thinning medication
  • You are allergic to aspirin or any other medication
  • You are taking other medication.

Pregnancy: Avoid. Potential risk to the foetus has been reported. Consult your doctor before use, or if you are planning to fall pregnant.

Breastfeeding: Avoid. It is unknown how this medication may affect your baby. Consult your doctor before use.

Porphyria: Avoid. It is unknown how this medication may affect your condition. Consult your doctor before use.

Infants and children: Safety and efficacy of this medication has not been established for children under the age of 12.

Elderly: Caution is advised in the elderly as side effects may be more likely. The dose may need to be adjusted.

Driving and hazardous work: Caution is advised as use of this medication may lead to dizziness, light-headedness and/or sedation. Avoid such activities until you know how this medication affects you.

Alcohol: Avoid concomitant use of alcohol with this medication as it may worsen stomach irritation.

Possible side effects

Side effect

Frequency

Consult your doctor

Common

Rare

Only if severe

In all cases

Gastrointestinal disorders

x

Headache

x

x

Dizziness

x

x

Drowsiness

x

x

Depression

x

x

Swelling (feet/ ankles)

x

x

Rash/itch

x

x

Difficulty breathing

x

x

Blood in vomit

x

Dark tarry stools

x

Interactions:

Drug interactions:

Blood pressure medication

Reduced pressure lowering effect

Alcohol

Potential gastrointestinal symptoms

Warfarin

Risk of bleeding

Asthma medication

Reduced effect of asthma medication; risk of asthma attack

Cardiac glycosides, digoxin

Risk that heart failure may be more severe.

Corticosteroids

Potential gastrointestinal symptoms

Ciclosporin

Potential Ketoprofen toxicity

Methotrexate

Potential methotrexate toxicity

Diuretics

Potential risk of kidney damage

Blood glucose lowering drugs

Risk of prolonged low blood sugar

Baclofen

Potential baclofen toxicity

Other NSAID's

Potential risk of gastrointestinal bleeding

Probenecid

Risk of Ketoprofen toxicity

Quionolone antibiotics

Risk of seizures

Tacrolimus

Increased risk of kidney damage

Zidovudine

Increased risk of zidovudine toxicity

Disease interactions

Consult your doctor before using this drug if you have asthma, a stomach ulcer, bleeding disorder, you are taking blood thinning medication, or if you are allergic to aspirin or any other medication.

Overdose action

A small overdose is no cause for concern. In case of intentional large overdose, seek emergency medical attention.

Recommended dosage

Adults: 100-200 mg/day

 

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