Meds and you

27 September 2013

Ivabradine

Ivabradine is an anti-anginal drug. Anti-anginal drugs are drugs that reduce the occurrence of angina.

0

Ivabradine is the active ingredient of Coralan film-coated tablets.

General information
Ivabradine is an anti-anginal drug. Anti-anginal drugs are drugs that reduce the occurrence of angina, a suffocating chest pain which results when partially clogged arteries restrict the flow of oxygen-rich blood to the heart.

In South Africa Ivabradine is registered for the treatment of symptomatic treatment of chronic stable angina pectoris in patients with normal sinus rhythm who have a contra-indication to, or intolerance to beta-blockers.

This medication does not cure the underlying condition, but simply keeps the symptoms under control. For it to be effective, it has to be taken regularly, even if you do not notice an immediate effect.

It should be noted that because this drug may cause dizziness, light-headedness and/or visual disturbances, driving and any hazardous tasks should be avoided until you know how this medication affects you.

How does ivabradine work?
Ivabradine lowers the heart rate. At usual recommended doses, heart rate reduction is approximately 10 beats per minute at rest and during exercise. This leads to a reduction in the workload of the heart and reduces its oxygen consumption.

Fast facts

Drug schedule: schedule 4
Available as: ivabradine is available as film-coated tablets.
What does it do? Ivabradine prevents chest pains.
Overdose risk: medium
Dependence risk: low
Is ivabradine available as a generic? no
Is ivabradine available on prescription only? yes

User information

Dietary advice: ivabradine should best be taken with or immediately after a meal.
Stopping this medicine: do not stop taking this drug without consulting your doctor.

Special precautions
Consult your doctor before using this drug if:

  • you have or had any heart disease
  • you have a pacemaker
  • you have very low blood pressure
  • your resting heart rate is below 60 beats per minute
  • you have liver or kidney disease
  • you have unstable angina pectoris
  • you are pregnant or plan to fall pregnant
  • you recently had a stroke
  • you are taking any other medication

Pregnancy: avoid. Potential risk to the foetus has been reported. Consult your doctor before use, or if you are planning to fall pregnant.
Breastfeeding: avoid. This medication is passed through breast milk and may affect your baby adversely. Consult your doctor before use.
Porphyria: avoid. It is unknown how this medication may affect your condition. Consult your doctor before use.
Infants and children: this medication is not intended for use in children under the age of 18 years.
The elderly: a lower starting dose should be considered in patients above the age of 75.
Alcohol: avoid concomitant use of alcohol with this medication.

Possible side effects

Side Effect
Frequency
Consult your doctor

Common
Rare
Only if severe
In all cases
enhanced brightness in visual field
X

X

blurred vision
X

X

slow heart rate

X
X

nausea/vomiting

X
X

diarrhoea

X
X

constipation

X
X

headache

X
X

dizziness

X
X

muscle cramps

X
X

palpitations

X

X

Interactions

Drug interactions

ketoconazole increase of the heart rate reduction observed with ivabradine
erythromycin increase of the heart rate reduction observed with ivabradine
azithromycin increase of the heart rate reduction observed with ivabradine
clarithromycin increase of the heart rate reduction observed with ivabradine
ciclosporin increase of the heart rate reduction observed with ivabradine
anti-retroviral drugs increase of the heart rate reduction observed with ivabradine
diltiazem increase of the heart rate reduction observed with ivabradine
verapamil increase of the heart rate reduction observed with ivabradine
grapefruit juice increase of the heart rate reduction observed with ivabradine
rifampicin reduced effect of ivabradine
barbiturates reduced effect of ivabradine
phenytoin reduced effect of ivabradine
St John's wort reduced effect of ivabradine
disopyramide increased risk of side effects with this drug
sotalol increased risk of side effects with this drug

Disease interactions
Consult your doctor before using this drug if you have or had any heart disease, you have a pacemaker, very low blood pressure, your resting heart rate is below 60 beats per minute, you have liver or kidney disease, unstable angina pectoris, or if you recently had a stroke.

Overdose action
Seek immediate emergency medical attention.

Recommended dosage
Adults, oral: 2.5 - 7.5 mg twice daily.

This material is not intended to substitute medical advice, but is for informational purposes only. Please consult a physician for specific treatment and recommendations.

 
 

Read Health24’s Comments Policy

Comment on this story
0 comments
Comments have been closed for this article.