Meds and you

27 September 2013

Imipenem and cilastin

Imipenem is a broad-spectrum antibiotic drug related to penicillin and cephalosporin antibiotics.

0

The combination of Imipenem and cilastin is the active ingredient found in Tienam (Nappi Code: 770779-018).

General information
Imipenem is a broad-spectrum antibiotic drug related to penicillin and cephalosporin antibiotics.

It is effectively applied in the treatment of septicaemia, endocarditis (a bacterial infection of the heart lining), lower respiratory tract, genitor-urinary tract, intra-abdominal, bone and joint, skin and soft tissue infections caused by organisms that are sensitive to imipenem.

The use of this antibiotic is generally limited to severe nosocomial infections - infections originating in a hospital environment, occurring in a patient in whom the infection was not present at time of admission.

Imipenem is hardly ever used on its own, and is generally combined with cilastin, a chemical that inhibits certain enzymes in the body to ensure that imipenem stays active in the body for longer. Cilastin itself does however have no antibacterial action.

The use of this antibiotic is reserved for hospital use only.

How does this combination work?
It works by interfering with bacterial ability to form cell walls, and therefore the bacteria break up and die.

Fast facts

Drug schedule: schedule 4
Available as: the combination of imipenem and cilastin is available as injection
What does it do? The combination of imipenem and cilastin has an antibiotic action
Overdose risk: medium
Dependence risk: low
Is this combination available as a generic? no
Is this combination available on prescription only? yes

Special precautions
Consult your doctor before using this drug if:

  • you have epilepsy

  • you are allergic to any antibiotics

  • you have any disorders of the central nervous system

  • you have kidney disease

  • you are taking any other medication

Pregnancy: avoid. Potential risk to the foetus has been reported. Consult your doctor before use, or if you are planning to fall pregnant.
Breastfeeding: avoid. This medication is passed through breast milk and may affect your baby adversely. Consult your doctor before use.
Porphyria: avoid. It is unknown how this medication may affect your condition. Consult your doctor before use.
Infants and children: this medication should only be used as prescribed by a paediatrician.
The elderly: caution is advised in the elderly and a reduced dose may be needed.

Possible side effects

Side Effect
Frequency
Consult your doctor

Common
Rare
Only if severe
In all cases
stomach pain
X

X

nausea / vommiting
X

X

diarrhoea
X

X

taste disturbances

X
X

skin rash/itch

X

X
convulsions

X

X
pain/inflammation at site of injection

X

X

Interactions

Drug interactions

ganciclovir increased impenem toxicity
theophylline increased risk of convulsion

Disease interactions
Consult your doctor before using this drug if you have epilepsy, are allergic to any antibiotics, have any disorders of the central nervous system or if you have kidney disease.

Recommended dosage
Adults: dose not to exceed 50 mg/kg/day up to a maximum daily dose of 4 g/day.
Children: only as prescribed by a paediatrician. Not to exceed 2 g/day.

This material is not intended to substitute medical advice, but is for informational purposes only. Please consult a physician for specific treatment and recommendations.
 
 

Read Health24’s Comments Policy

Comment on this story
0 comments
Comments have been closed for this article.