Updated 11 February 2013


Hyoscine-N-butylbromide is an antispasmodic drug used to treat conditions associated with spasms of the gastrointestinal tract, such as cramping.


Hyoscine-N-butylbromide is the active ingredient of Buscopan, Hyospasmol and Micro Hyoscine Butylbromide.

Hyoscine-N-butylbromide is also one of multiple active ingredients found in Buscopan Co and Scopex Co (both hyoscine-N-butylbromide and dipyrone).

General information

Hyoscine-N-butylbromide is an antispasmodic drug used to treat conditions associated with spasms of the gastrointestinal tract, such as cramping.

It can also be used in combination with other drugs to relieve painful menstruation.

How does it work?

This medication relieves gastrointestinal cramping by relieving smooth muscle contractions.

Fast facts

Drug schedule: Schedule 2

Available as: Tablets, syrup, and injection

What does it do? Relieve cramps

Overdose risk: Medium

Dependence risk: Low

Available as a generic? Yes

Available on prescription only? No

User information

Onset of effect: Within 2 hours.

Duration of action: Up to 10 hours.

Stopping: This medication can be safely stopped when no longer needed. If your doctors have prescribed it for long-term use, you should consult them before stopping.

Prolonged use: No problems expected.

Special precautions

Consult your doctor before using this drug if:

  • you have glaucoma
  • you have obstructive bowel disorder
  • you have an enlarged prostate
  • you have liver or kidney disease
  • you have myasthenia gravis
  • you have heart disease
  • you are taking other medication

Pregnancy: Avoid. Potential risk to the foetus has been reported. Consult your doctor before use, or if you are planning to fall pregnant.

Breastfeeding: Avoid. It is unknown how this medication may affect your baby. Consult your doctor before use.

Porphyria: Avoid. It is unknown how this medication may affect your condition. Consult your doctor before use.

Infants and children: This medication is safe for use in children at the recommended dose.

Elderly: Caution is advised in the elderly and a reduced dose may be needed.

Driving and hazardous work: Caution is advised as use may lead to dizziness, light-headedness and/or sedation. Avoid such activities until you know how it affects you.

Alcohol: Avoid concomitant use as it may increase sedative effects of this drug.

Possible side effects

Side effect


Consult your doctor



Only if severe

In all cases

Dry mouth



Visual disturbance






Drowsiness/ fatigue



Flushing/ warm dry skin



Difficulty urinating







Drug interactions

Anticholinergic drugs

Increased anticholinergic effects (dry mouth, urinary retention, constipation, confusion in the elderly)

Sedative drugs

Increased sedative effects

Disease interactions

Consult your doctor before using this drug if you have glaucoma, obstructive bowel disorder, an enlarged prostate, liver or kidney disease, myasthenia gravis, or if you have heart disease.

Overdose action

A small overdose is no cause for concern. In case of intentional large overdose seek emergency medical attention.

Recommended dosage

Adults: 10-20 mg 3-4 times daily with a maximum daily dose of 100 mg.

Children: 1-3 months: 1.5 mg 3 times a day

3-12 months: 2.5-5 mg 3 times a day

1-3 years: 5-10 mg 3 times a day

3-6 years: 10 mg 3 times a day

6-12 years: 10-20 mg 3 times a day

This material is not intended to substitute medical advice, but is for informational purposes only. Please consult a physician for specific treatment and recommendations.


Read Health24’s Comments Policy

Comment on this story
Comments have been closed for this article.

Live healthier

PMS, depression & suicide »

Don't let PMS get you down Symptoms of PMS Diagnosing PMS

The link between PMS, depression and suicidal thoughts

The symptoms of premenstrual dysphoric disorder (PMDD) are similar to those of PMS, but generally more severe – and could include depression and even thoughts of suicide.

A vegan marathon runner »

Comrades: don't run if you're ill Fuel your body for the Comrades

Running the Comrades Marathon on a vegan diet

Donovan Will, who is training to run the Comrades Marathon, speaks to Health24 about his plant based diet and fears of getting injured ahead of the big race.