Meds and you

27 September 2013

Griseofulvin

Griseofulvin is an antimycotic drug. Antimycotics are drugs that destroy or prevent the growth of fungi. An antimycotic drug is thus an antifungal drug.

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Griseofulvin is the active ingredient of Microcidal (Nappi Code: 729566-005 & 729574-008/16).

General information
Griseofulvin is an antimycotic drug. Antimycotics are drugs that destroy or prevent the growth of fungi. An antimycotic drug is thus an antifungal drug.

In South Africa griseofulvin is registered for the treatment of diseases of the skin, hair and nails due to susceptible fungal infections. Griseofulvin also is highly effective in treating "athlete's foot".

The absorption of this drug is enhanced if taken with a fatty meal or with a glass of milk.

Treatment with griseofulvin should only be stopped once the prescribed course has been completed, or if your doctor instructs you to do so.

Griseofulvin may cause your skin to be more sensitive to sunlight than usual. It is advised to avoid excessive sun-exposure while taking this drug.

This medication is only effective in treating fungal infections and will not be effective in treating bacterial or viral infections.

How does griseofulvin work?
Griseofulvin works by binding to a protein (keratin) in the human body as it forms. Instead of killing fungal infections, it prevents fungal infections from infecting the newly formed keratin. With time the infected keratin is shed, leaving behind the uninfected keratin cells.

Fast facts

Drug schedule: schedule 4
Available as: griseofulvin is available as tablets
What does it do? Griseofulvin destroys or prevents the growth of fungi
Overdose risk: low
Dependence risk: low
Is griseofulvin available as a generic? yes
Is griseofulvin available on prescription only? yes

User information

Onset of effect: an adequate response may require months of treatment.
Dietary advice: the absorption of this drug is enhanced if taken with a fatty meal or with a glass of milk.
Stopping this medicine: do not stop taking griseofulvin without consulting your doctor. If you stop taking this medicine too soon, your symptoms may return.

Special precautions
Consult your doctor before using this drug if:

  • you have a liver disease

  • you have porphyria

  • you have been diagnosed with systemic lupus erythematosus

  • you are allergic to penicillin

Pregnancy: avoid. Potential risk to the foetus has been reported. Consult your doctor before use, or if you are planning to fall pregnant.
Breastfeeding: avoid. It is unknown how this medication may affect your baby. Consult your doctor before use.
Porphyria: avoid. It is unknown how this medication may affect your condition. Consult your doctor before use.
Infants and children: this medication is safe for use in children at the recommended dose.
The elderly: caution is advised in the elderly.
Driving and hazardous work: caution is advised as use of this medication may lead to dizziness, light-headedness and/or sedation. Avoid such activities until you know how this medication affects you.
Alcohol: avoid concomitant use of alcohol with this medication.

Possible side effects

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Side Effect

Frequency
Consult your doctor

Common
Rare
Only if severe
In all cases

headache

X
X

dry mouth

X
X

altered sense of taste

X
X

mild skin rash

X
X

swelling

X
X

severe skin reactions

X
X

dizziness

X
X

confusion

X
X

impaired judgement

X
X

depression

X
X

Interactions

alcohol nausea and vomiting
warfarin reduced effect of warfarin
barbiturates reduced effect of griseofulvin
oral contraceptives reduced efficacy of pill

Overdose action
A small overdose is no cause for concern. In case of intentional large overdose, seek emergency medical attention.

Recommended dosage
Adult, 10 mg/kg up to 1g daily as a single or as divided doses

This material is not intended to substitute medical advice, but is for informational purposes only. Please consult a physician for specific treatment and recommendations.
 
 

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