Griseofulvin is the active ingredient of Microcidal (Nappi Code: 729566-005
Griseofulvin is an antimycotic drug.
Antimycotics are drugs that destroy or prevent the growth of fungi. An
antimycotic drug is thus an antifungal drug.
In South Africa griseofulvin is registered for the treatment of diseases of
the skin, hair and nails due to susceptible fungal infections. Griseofulvin also
is highly effective in treating "athlete's foot".
The absorption of this drug is enhanced if taken with a fatty meal or with a
glass of milk.
Treatment with griseofulvin should only be stopped once the prescribed course
has been completed, or if your doctor instructs you to do so.
Griseofulvin may cause your skin to be more sensitive to sunlight than usual.
It is advised to avoid excessive sun-exposure while taking this drug.
This medication is only effective in treating fungal infections and will not
be effective in treating bacterial or viral infections.
How does griseofulvin work?
Griseofulvin works by binding to a
protein (keratin) in the human body as it forms. Instead of killing fungal
infections, it prevents fungal infections from infecting the newly formed
keratin. With time the infected keratin is shed, leaving behind the uninfected
Drug schedule: schedule 4
Available as: griseofulvin is
available as tablets
What does it do? Griseofulvin destroys or
prevents the growth of fungi
Overdose risk: low
Is griseofulvin available as a generic? yes
griseofulvin available on prescription only? yes
Onset of effect: an adequate response may require months of
Dietary advice: the absorption of this drug is enhanced if
taken with a fatty meal or with a glass of milk.
medicine: do not stop taking griseofulvin without consulting your doctor. If
you stop taking this medicine too soon, your symptoms may return.
Consult your doctor before using this drug
- you have a liver disease
- you have porphyria
- you have been diagnosed with systemic lupus erythematosus
- you are allergic to penicillin
Pregnancy: avoid. Potential risk to the foetus has been reported.
Consult your doctor before use, or if you are planning to fall
Breastfeeding: avoid. It is unknown how this medication may
affect your baby. Consult your doctor before use.
Porphyria: avoid. It
is unknown how this medication may affect your condition. Consult your doctor
Infants and children: this medication is safe for use in
children at the recommended dose.
The elderly: caution is advised in
Driving and hazardous work: caution is advised as use of
this medication may lead to dizziness, light-headedness and/or sedation. Avoid
such activities until you know how this medication affects
Alcohol: avoid concomitant use of alcohol with this
Possible side effects
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Consult your doctor
Only if severe
In all cases
altered sense of taste
mild skin rash
severe skin reactions
||nausea and vomiting|
||reduced effect of warfarin|
||reduced effect of griseofulvin|
||reduced efficacy of pill|
A small overdose is no cause for concern. In case
of intentional large overdose, seek emergency medical attention.
Adult, 10 mg/kg up to 1g daily as a single or
as divided doses
This material is not intended to substitute medical advice, but is
for informational purposes only. Please consult a physician for specific
treatment and recommendations.