Meds and you

Updated 11 February 2013

Desloratadine

Desloratadine is an active metabolite of loratadine. It is an antihistamine used for the treatment of allergic conditions, mainly hay fever and skin conditions.

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Desloratadine is the active ingredient of Deselex.

General information

Desloratadine is an active metabolite of loratadine. It is an antihistamine used for the treatment of allergic conditions, mainly hay fever and skin conditions. Unlike many older antihistamines, Desloratadine has very little sedative effects, meaning that you won’t feel drowsy after taking this drug. It may still cause drowsiness in a small percentage of those taking it.

Desloratadine has a long-acting effect and only needs to be taken once a day.

How does desloratadine work?

When you are exposed to an allergen - something you are allergic to - your body reacts by producing chemical called histamine. Histamine causes the symptoms that we associate with allergy. These include itchy, red, watery eyes; sneezing and runny, itchy nose; postnasal drip; and an itchy, sometimes visibly red skin.

Desloratadine is an antihistamine, meaning that it counteracts the action of histamine to help relieve you of the symptoms of allergy.

Fast facts

Drug schedule: schedule 2

Available as: desloratadine is available as tablets and syrup

What does it do? desloratadine has an anti-allergy effect

Overdose risk: low

Dependence risk: low

Is Desloratadine available as a generic? no

Is Desloratadine available on prescription only? no

User information

Onset of effect: within 1 hour

Duration of action: up to 24 hours

Dietary advice: desloratadine can be taken with or without food

Stopping this medicine:d Desloratadine can be safely stopped when no longer needed

Prolonged use: no special precautions

Special precautions

Consult your doctor before using this drug if:

  • you have kidney or liver disease
  • you have a known allergy to the product
  • you are taking other medication

Pregnancy: Avoid. It is unknown how this medication may affect your baby. Consult your doctor before using this drug, or if you are planning to fall pregnant

Breastfeeding: Avoid. It is unknown how this medication may affect your baby. Consult your doctor before use.

Porphyria: Avoid. It is unknown how this medication may affect your condition. Consult your doctor before use.

Infants and children: Safety and efficacy of this medication has not been established for children under the age of 2.

The elderly: No special precautions need to be taken.

Driving and hazardous work: Caution is advised as use of this medication may, although unlikely, lead to dizziness, light-headedness and/or sedation. Avoid such activities until you know how this medication affects you.

Alcohol: Avoid concomitant use of alcohol with this medication.

Possible side effects

Side effect

Frequency

Consult your doctor

Common

Rare

Only if severe

In all cases

nausea

x

x

fatigue

x

x

headache

x

x

dry mouth

x

x

palpitations/ tremors

x

x

Interactions

Drug interactions

cimetidine

potential risk of desloratadine toxicity

barbiturates

potential for enhanced sedation

benzodiazepines

potential for enhanced sedation

hypnotics

potential for enhanced sedation

sedatives

potential for enhanced sedation

Overdose action

A small overdose is no cause for concern. In case of an intentional large overdose seek emergency medical attention. Symptoms may include confusion and nausea.

Recommended dosage

Adults: 5 mg once daily

This material is not intended to substitute medical advice, but is for informational purposes only. Please consult a physician for specific treatment and recommendations.

 

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