Meds and you

27 September 2013

Clothiapine

Clothiapine is an anti-psychotic. Anti-psychotics are drugs that are used to treat psychosis, a state of mind in which thinking becomes irrational and/or disturbed.

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(Also known as clotiapine)

Clothiapine is the active ingredient of Etomine tablets (Nappi code:724777-008) & Etomine injection (Nappi code:724785-019).

General information
Clothiapine is an anti-psychotic. Anti-psychotics are drugs that are used to treat psychosis, a state of mind in which thinking becomes irrational and/or disturbed and which may include delusions, hallucinations, and severe thought disturbances.

In South Africa clothiapine is registered for the treatment of psychoses as a result of schizophrenia, and depression with associated excitatory and neurotic symptoms.

This medication does not cure the underlying condition causing psychoses, but simply keeps the symptoms under control. For this medication to be effective it has to be taken regularly, even if you do not notice an immediate effect.

Treatment should not be stopped abruptly, especially if you have been taking this drug for a prolonged period of time. To reduce the risk of rebound psychoses, you should decrease your dose gradually only as directed by your doctor.

It should be noted that because this drug may cause dizziness, light-headedness and/or sedation, driving and any hazardous tasks should be avoided until you know how this medication affects you.

How does clothiapine work?
Clothiapine has an effect on a chemical messenger in the brain called dopamine. Dopamine plays an important role in, amongst others, regulating mood and behavior. Conditions such as schizophrenia and associated psychosis are associated with an over-activity of dopamine in the brain. Clothiapine reduces the effect of this chemical in the brain, thereby relieving symptoms.

Fast facts

Drug schedule: schedule 5
Available as: clothiapine is available as tablets and injections.
What does it do? Clothiapine reduces the occurrence of psychoses.
Overdose risk: medium
Dependence risk: medium
Is clothiapine available as a generic? no
Is clothiapine available on prescription only? yes

User information

Stopping this medicine: do not stop using this medication abruptly as there is a risk of rebound psychosis. It is advised that you decrease your dose gradually as directed by your doctor - preferably over 7-14 days.
Prolonged use: regular blood and liver-function tests are advised with prolonged use.

Special precautions Consult your doctor before using this drug if:

  • you have epilepsy

  • you are under the influence of alcohol

  • you are taking other medication

  • you have kidney or liver disease

  • you have been diagnosed with a cardiovascular disorder

  • you have an enlarged prostate

  • you have glaucoma

Pregnancy: avoid. It is unknown how this medication may affect your baby. Consult your doctor before using this drug, or if you are planning to fall pregnant.
Breastfeeding: avoid. This medication is passed through breast milk and may affect your baby adversely. Consult your doctor before use.
Porphyria: avoid. It is unknown how this medication may affect your condition. Consult your doctor before use.
Infants and children: this medication is not intended for use in children.
The elderly: caution is advised in the elderly as side effects are more likely to occur.
Driving and hazardous work: this medication should be avoided as it may cause extreme sedation.
Alcohol: avoid concomitant use of alcohol with this medication.

Possible side effects

Side Effect
Frequency
Consult your doctor

Common
Rare
Only if severe
In all cases
drowsiness
X

X

involuntary facial and body movements

X
X

dry mouth

X
X

low blood pressure

X
X

dizziness with sudden movements

X
X

diarrhoea

X
X

nausea/vomiting

X
X

palpitations

X

X
visual distrubances

X

X
skin rash

X

X
flu-like symptoms

X

X
seizures

X

X
agitation

X

X
confusion

X

X
swelling

X

X
abnormally high body temperature

X

X

Interactions
Drug interactions

alcohol enhanced CNS depression
benzodiazepines enhanced CNS depression
antidepressants enhanced CNS depression
antihistamines enhanced CNS depression
lithium enhanced toxicity enhanced
warfarin risk of warfarin toxicity
digoxin risk of digoxin toxicity

Disease interactions
Consult your doctor before using this drug if you have a history of convulsions, you have kidney or liver disease, you have been diagnosed with a cardiovascular disorder, you have an enlarged prostate, or if you have glaucoma.

Overdose action
A small overdose is no cause for concern. In case of intentional large overdose, seek emergency medical attention.

Recommended dosage
Adults, oral: 20 - 80 mg/day up to a maximum of 360 mg/day.

This material is not intended to substitute medical advice, but is for informational purposes only. Please consult a physician for specific treatment and recommendations.
 
 

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