Clopidrogel is the active ingredient of Plavix.
General Information
Clopidrogel is an antiplatelet medicine - it prevents blood clot formation in arteries by reducing the stickiness of platelets in blood. It is prescribed in those at risk of stroke and heart attack.
Although clopidrogel is a suitable alternative in those who can't tolerate aspirin, it may still cause similar side effects, including stomach upset and/or stomach ulcers.
Clopidrogel should not be prescribed to those taking warfarin as it may increase the risk of bleeding.
How does clopidrogel work?
Clopidrogel prevents stroke (when a blood clot prevents blood flow to parts of the brain) or heart attack (when a blood clot prevents blood flow to parts of the heart) by discouraging blood clot formation.
Fast facts
Drug schedule: Schedule 3
Available as: Tablets
What does it do? Clopidrogel prevents blood clotting
Overdose risk: Medium
Dependence risk: Low
Available as a generic? No
Available on prescription only? Yes
User information
Onset of effect: Within 2 hours.
Duration of action: Up to 24 hours.
Dietary advice: Clopidrogel can be taken with or without food.
Stopping this medicine: Do not stop taking this drug without speaking to your doctor.
Prolonged use: Side effects are more likely to occur with long-term use.
Special precautions
Consult your doctor before using this drug if:
- you have a stomach ulcer,
- you have liver or kidney disease,
- you have a condition that make you more likely to bleed, or a history of
- bleeding problems, including bleeding on the brain,
- you are taking other medication, or
- you are planning to have surgery.
Pregnancy: Avoid. It is unknown how this medication may affect your baby. Consult your doctor before using this drug, or if you are planning to fall pregnant
Breastfeeding: Avoid. This medication is passed through breast milk and may affect your baby adversely. Consult your doctor before use.
Porphyria: Avoid. It is unknown how this medication may affect your condition. Consult your doctor before use.
Infants and children: This medication is not intended for use in children.
Elderly: No special precautions need to be taken.
Driving and hazardous work: No special precautions need to be taken.
Alcohol: Avoid concomitant use of alcohol with this medication as it may increase stomach irritation
Possible side effects
Side effect |
Frequency |
Consult your doctor |
Common |
Rare |
Only if severe |
In all cases |
Nausea/ vomiting |
x |
|
x |
|
Diarrhoea/ stomach pain |
x |
|
x |
|
Stomach ulceration |
|
x |
|
x |
Abnormal bruising/ nosebleeds |
|
x |
|
x |
Dizziness/ light-headedness/ weakness |
|
x |
|
x |
Headache |
x |
|
x |
|
Skin rash/ itching |
|
x |
|
x |
Body/ joint aches or pain |
|
x |
x |
|
Anaemia |
|
x |
|
x |
Anxiety |
|
x |
x |
|
Chest pain/ shortness of breath |
|
x |
|
x |
High fever/ severe infection |
|
x |
|
x |
Interactions:
Drug interactions:
Aspirin |
Increased risk of bleeding |
Non-steroidal anti-inflammatory drugs |
Increased risk of bleeding |
Phenytoin |
Increased risk of phenytoin toxicity |
Warfarin |
Increased risk of bleeding |
Cimetidine |
Increased risk of Clopidrogel side effects |