Meds and you

Updated 11 February 2013


Cefpodoxime is a broad spectrum antibiotic, effective in treating a variety of bacterial infections.


Cefpodoxime is the active ingredient of Orelox, Cepodem and Simayla Cefpodoxime.

General Information

Cefpodoxime is a broad spectrum antibiotic, effective in treating a variety of bacterial infections. It is frequently prescribed to treat acute and chronic bronchitis, pharyngitis and tonsillitis, community-acquired bronchopneumonia, acute sinusitis and middle-ear infections, caused by organisms that are susceptible to cefpodoxime.

It is important to note that this medication is only effective against bacterial infections - if your infection is the result of a viral or fungal infection, it will be ineffective.

Antibiotic resistance - when bacteria develop the ability to defend themselves against the effect of an antibiotic - occurs frequently with many antibiotics. It mostly happens when patients do not complete the prescribed course in full, allowing bacteria to recover from treatment, and by using antibiotics for non-bacterial infections such as cold and flu.

Persons who are allergic to penicillin should take cefpodoxime with caution. Although it is not penicillin, cross-sensitivity - meaning that you may be allergic to this drug - may occur.

How does cefpodoxime work?

Cefpodoxime weakens the bacterial cell wall and allows water to enter the cell, causing cells to burst.

Fast facts

Drug schedule: Schedule 4

Available as: Cefpodoxime is available as tablets and a suspension.

What does it do? This medication has an antibiotic effect.

Overdose risk: Low

Dependence risk: Low

Is cefpodoxime available as a generic? Yes

Is cefpodoxime available on prescription only? Yes

User information

Dietary advice: This medication should be taken with food.

Stopping this medicine: Do not stop taking this medication until you have finished the course as prescribed by your doctor - infection may recur with premature discontinuation.

Prolonged use: Cefpodoxime is usually given only for short courses of treatment.

Special precautions

Consult your doctor before using this drug if:

  • You have a kidney disease
  • You allergic other cephalosporins or penicillin
  • You are taking other medication.

Pregnancy: Avoid. It is unknown how this medication may affect your baby. Consult your doctor before using this drug, or if you are planning to fall pregnant.

Breastfeeding: Avoid. This medication is passed through breast milk and may affect your baby adversely. Consult your doctor before use.

Porphyria: Avoid. This medication may cause serious adverse effects. Consult your doctor before use.

Infants and children: This medication is safe for use in children at the recommended dose.

Elderly: Caution is advised in the elderly, as adverse effects may be more severe.

Driving and hazardous work: Driving and hazardous work

Alcohol: Caution is advised, as use of this medication may lead to dizziness, light-headedness and/or sedation. Avoid such activities until you know how this medication affects you.

Possible side effects

Side effect


Consult your doctor



Only if severe

In all cases




Stomach cramps



Nausea and vomiting



Rash/ hives/ itchy skin






Breathing difficulties



Swelling of face/ throat



Fever/ sweating



Bloody diarrhoea




Drug interactions


Increased risk of warfarin toxicity

Non-steroidal anti-inflammatory drugs

Increased risk of bleeding


Drugs may counteract each other

Vancomycin/ aminoglycoside antibiotics

Increased risk of kidney toxicity

Oral contraceptives

Risk of contraceptive failure


Increased levels of antibiotic in body

Overdose action

A small overdose is no cause for concern. In case of intentional large overdose, seek emergency medical attention. Symptoms may include seizures, severe abdominal pain and vomiting.

Recommended dosage

Adult dose: 100-200 mg twice a day

Children: 5mg/kg/dose (maximum 200 mg) every 12 hours


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