Meds and you

Updated 11 February 2013

Cefpodoxime

Cefpodoxime is a broad spectrum antibiotic, effective in treating a variety of bacterial infections.

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Cefpodoxime is the active ingredient of Orelox, Cepodem and Simayla Cefpodoxime.

General Information

Cefpodoxime is a broad spectrum antibiotic, effective in treating a variety of bacterial infections. It is frequently prescribed to treat acute and chronic bronchitis, pharyngitis and tonsillitis, community-acquired bronchopneumonia, acute sinusitis and middle-ear infections, caused by organisms that are susceptible to cefpodoxime.

It is important to note that this medication is only effective against bacterial infections - if your infection is the result of a viral or fungal infection, it will be ineffective.

Antibiotic resistance - when bacteria develop the ability to defend themselves against the effect of an antibiotic - occurs frequently with many antibiotics. It mostly happens when patients do not complete the prescribed course in full, allowing bacteria to recover from treatment, and by using antibiotics for non-bacterial infections such as cold and flu.

Persons who are allergic to penicillin should take cefpodoxime with caution. Although it is not penicillin, cross-sensitivity - meaning that you may be allergic to this drug - may occur.

How does cefpodoxime work?

Cefpodoxime weakens the bacterial cell wall and allows water to enter the cell, causing cells to burst.

Fast facts

Drug schedule: Schedule 4

Available as: Cefpodoxime is available as tablets and a suspension.

What does it do? This medication has an antibiotic effect.

Overdose risk: Low

Dependence risk: Low

Is cefpodoxime available as a generic? Yes

Is cefpodoxime available on prescription only? Yes

User information

Dietary advice: This medication should be taken with food.

Stopping this medicine: Do not stop taking this medication until you have finished the course as prescribed by your doctor - infection may recur with premature discontinuation.

Prolonged use: Cefpodoxime is usually given only for short courses of treatment.

Special precautions

Consult your doctor before using this drug if:

  • You have a kidney disease
  • You allergic other cephalosporins or penicillin
  • You are taking other medication.

Pregnancy: Avoid. It is unknown how this medication may affect your baby. Consult your doctor before using this drug, or if you are planning to fall pregnant.

Breastfeeding: Avoid. This medication is passed through breast milk and may affect your baby adversely. Consult your doctor before use.

Porphyria: Avoid. This medication may cause serious adverse effects. Consult your doctor before use.

Infants and children: This medication is safe for use in children at the recommended dose.

Elderly: Caution is advised in the elderly, as adverse effects may be more severe.

Driving and hazardous work: Driving and hazardous work

Alcohol: Caution is advised, as use of this medication may lead to dizziness, light-headedness and/or sedation. Avoid such activities until you know how this medication affects you.

Possible side effects

Side effect

Frequency

Consult your doctor

Common

Rare

Only if severe

In all cases

Diarrhoea

x

x

Stomach cramps

x

x

Nausea and vomiting

x

x

Rash/ hives/ itchy skin

x

x

Confusion/light-headedness

x

x

Breathing difficulties

x

x

Swelling of face/ throat

x

x

Fever/ sweating

x

x

Bloody diarrhoea

x

x

Interactions

Drug interactions

Warfarin

Increased risk of warfarin toxicity

Non-steroidal anti-inflammatory drugs

Increased risk of bleeding

Chloramphenicol

Drugs may counteract each other

Vancomycin/ aminoglycoside antibiotics

Increased risk of kidney toxicity

Oral contraceptives

Risk of contraceptive failure

Probenecid

Increased levels of antibiotic in body

Overdose action

A small overdose is no cause for concern. In case of intentional large overdose, seek emergency medical attention. Symptoms may include seizures, severe abdominal pain and vomiting.

Recommended dosage

Adult dose: 100-200 mg twice a day

Children: 5mg/kg/dose (maximum 200 mg) every 12 hours

 

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